phytotoxic

Homodihydrocapsaicin I 是一种辣椒素，分离自辣椒果实中。

Methyl 2,4-dihydroxyphenylacetate 是从 Nigella damascena 种子中分离得到的天然产物，具有选择性的植物毒性作用。

Simazine (Tafazine) 是三嗪类除草剂，普遍用于农业、盆栽植物和树木的生产。它具有植物毒性，但对土壤微生物和藻类毒性较低。

Tulipalin A (α-methylene-γ-butyrolactone) 是来源于郁金香鳞茎的有毒糖苷。Tulipalin A 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen)，在低剂量影响免疫细胞的功能，例如 Jurkat T 细胞。

Alternariol 是从 Etoac 提取的天然产物，在小鼠肝癌细胞与人血清体系中表现出抗炎活性，并影响 TLR 信号通路及促凋亡蛋白表达。同时研究显示 Alternariol 对甲基转移酶不具抑制作用，为其代谢失活特征提供参考。

Apiol analogous是一种Apiole的类似物，广泛应用于生物化学实验。Apiole可作为抗氧化剂、抗真菌剂、抗癌剂、流产剂、杀螨剂和植物毒性剂，能够影响下丘脑-垂体轴，调节月经周期，诱导 G0/G1 细胞周期停滞而抑制癌细胞。

Radicinin is used as a phytotoxic and antibiotic metabolite produced by some phytopathogenic fungi.

AM Toxin III is a phytotoxic peptide.

Rubrobramide is a cytotoxic and phytotoxic metabolite from Cladobotyrum rubrobrunnescens.

β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate. β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo. β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L. sativa seedlings.

Carviolin 是在紫红青霉、纯真新保加利亚霉和青霉中发现的一种天然产物，具有中等细胞毒性。Carviolin 具有抗真菌、抗菌或植物毒性活性。

Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 |1. Yeh, S.F., Pan, W., Ong, G.-T., et al. Study of structure-activity correlation in destruxins, a class of cyclodepsipeptides possessing suppressive effect on the generation of hepatitis B virus surface antigen in human hepatoma cells. Biochem. Biophys. Res. Commun. 229(1), 65-72 (1996).|2. Male, K.B., Tzeng, Y.-M., Montes, J., et al. Probing inhibitory effects of destruxins from Metarhizium anisopliae using insect cell based impedance spectroscopy: Inhibition vs chemical structure. Analyst 134(7), 1447-1452 (2009).|3. Buchwaldt, L., and Green, H. Phytotoxicity of destruxin B and its possible role in the pathogenesis of Alternaria brassicae. Plant Pathol. 41(1), 55-63 (1992).

Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay.

Papyracillic acid is a fungal metabolite and a derivative of penicillic acid originally isolated fromL. papyraceumand has antibiotic, antifungal, and phytotoxic activities.1,2It is active against the bacteriaX. campestrisandB. subtilisand the fungusC. tropicalisin a disc assay when used at a concentration of 5 μg/disc.2Papyracillic acid (1 mg/ml) induces necrotic lesion formation in a panel of 10 plants. 1.Shan, R., Anke, H., Stadler, M., et al.Papyracillic acid, a new penicillic acid analogue from the Ascomycete Lachnum papyraceumTetrahedron52(30)10249-10254(1996) 2.Evidente, A., Berestetskiy, A., Cimmino, A., et al.Papyracillic acid, a phytotoxic 1,6-dioxaspiro[4,4]nonene produced by Ascochyta agropyrina Var. nana, a potential mycoherbicide for Elytrigia repens biocontrolJ. Agric. Food Chem.57(23)11168-11173(2009)

Pentabromopseudilin (PBrP) 为自Pseudomonas bromoutilis与Alteromonas luteoviolaceus两种海洋细菌中提取的海洋抗生素，展现抗菌、抗肿瘤及植物毒性活性。此化合物为肌球蛋白 Va(Myosin Va, MyoVa)的可逆构型抑制剂，并能有效抑制转化生长因子-β(Transforming Growth Factor-β, TGF-β)的活性，适用于纤维化疾病与癌症研究领域。

Altersolanol A（Stemphylin; NSC 173943）在对抗Bacillus subtilis和Pseudomonas aeruginosa方面显示出抗菌活性，其MIC范围为25-100 μg/mL。此外，Altersolanol A在4 μg/μL剂量下对红豆杉 (Taxus) 没有植物毒性。

Alternariol (Standard) is the standard substance of Alternariol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.

Neobulgarone E 是从子囊菌纲真菌 Neobulgaria pura HA A07-97 中提取的蒽醌衍生物。它能够抑制稻瘟病菌附着胞的形成，同时表现出一定的细胞毒性，但不具有抗真菌、抗菌和植物毒性。

Neobulgarone D 是一种由子囊菌纲真菌 Neobulgaria pura HA A07-97 生成的蒽醌衍生物。Neobulgarone D 能抑制稻瘟病菌附着胞形成，并显示出轻微的细胞毒性，但不具抗真菌、抗菌和植物毒性。

Neobulgarone F 是一种蒽醌衍生物，来自子囊菌纲真菌 Neobulgaria pura HA A07-97。Neobulgarone F 能抑制稻瘟病菌附着胞的形成，显示出一定程度的细胞毒性，但不具抗真菌、抗菌和植物毒性。

Neobulgarone C 是一种来源于子囊菌纲真菌 Neobulgaria pura HA A07-97 的蒽醌衍生物。Neobulgarone C 能够抑制稻瘟病菌附着胞的生成，并具有轻微的细胞毒性，但不具备抗真菌、抗菌或植物毒性。

Neobulgarone A 是一种源自子囊菌纲真菌 Neobulgaria pura HA A07-97 的蒽醌衍生物。它能够抑制稻瘟病菌附着胞的形成，表现出一定的细胞毒性，但并无抗真菌、抗菌或植物毒性。

Neobulgarone B 是一种蒽醌衍生物，来源于子囊菌纲真菌 Neobulgaria pura HA A07-97。Neobulgarone B 能够抑制稻瘟病菌附着胞的形成，其细胞毒性较弱，但不具抗真菌、抗菌和植物毒性。

Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3.