paroxetine

Paroxetine 是选择性血清素再摄取抑制剂，是苯基哌啶的衍生物。 它对于甲肾上腺素摄取抑制功能较弱，但比该位点其他SSRIs 更有效。

Paroxetine hydrochloride (Paroxetine HCl) 是一种血清素摄取抑制剂，能抑制 GRK2 活性，IC50值为 14 μM。它可研究抑郁症。

Paroxetine maleate is a selective inhibitor of serotonin reuptake and an antidepressant.

N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.

rac-Paroxetine-d4 Hydrochloride 是 rac-Paroxetine Hydrochloride 的氘代化合物。rac-Paroxetine Hydrochloride 的 CAS 号为 78246-49-8。Paroxetine hydrochloride 是一种血清素摄取抑制剂，能抑制 GRK2 活性，IC50值为 14 μM。它可研究抑郁症。

Paroxetine hydrochloride hemihydrate (Paxil) 是一种抗抑郁药，为高效的五羟色胺再摄取抑制剂，能抑制 GRK2 活性，IC50 为 14 μM。

Paroxetine Mesylate, the mesylate salt form of paroxetine, is a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with anxiolytic and antidepressant properties.

Desmethylene Paroxetine hydrochloride 是 Paroxetine 的非共轭代谢产物，是一种儿茶酚中间体。

Paroxetine-d4 HCl 是 Paroxetine HCl 的氘代化合物。Paroxetine HCl 的 CAS 号为 78246-49-8。Paroxetine hydrochloride 是一种血清素摄取抑制剂，能抑制 GRK2 活性，IC50值为 14 μM。它可研究抑郁症。

PIM-35，一种具有类似抗抑郁剂特性的吲哚衍生物，与标准物相比，其抑制去甲肾上腺素摄取的能力较弱。长期使用PIM-35对alpha 2、beta 1-和beta 2-肾上腺素受体的数量和亲和力均无影响。此外，PIM-35对5-羟色胺系统具有作用，与帕罗西汀和氯米帕明这类抗抑郁化合物有相似之处。

CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.

GRKs-IN-1 hydrochloride, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=130 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 hydrochloride is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1]. [1]. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.

Paroxol methanesulfonate is an intermediate in the synthesis of Paroxetine, a selective serotonin reuptake inhibitor.