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抑制剂&激动剂
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TargetMol产品目录中 "o11"的结果
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TargetMol产品目录中 "

o11

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  • 抑制剂&激动剂
    69
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    17
    TargetMol | Recombinant_Protein
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    1
    TargetMol | Inhibitory_Antibodies
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    1
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    TargetMol | Natural_Products
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    TargetMol | Isotope_Products
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    17
    TargetMol | Antibody_Products
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  • 分子与细胞研究
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    TargetMol | Inhibitors_Agonists
  • O-11
    T35904119290-12-9
    O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)
    • 待估
    35日内发货
    规格
    数量
  • SHO1122147
    T204360
    SHO1122147 (Compound 7m) 通过影响线粒体电子传递链展现出线粒体解偶联活性(EC50=3.6 μM),提升细胞耗氧率(OCR=69%)并促进细胞呼吸。SHO1122147 具备口服活性,适用于肥胖和代谢功能障碍相关脂肪性肝炎 (MASH) 的研究。
    • 待询
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  • RO116-4875/608
    RO 116-4875 608
    T34367270251-12-2
    RO116-4875 608 is bioactive chemical.
    • 待询
    规格
    数量
  • RO116-9132/238
    RO-116-9132 238,RO 116-9132 238
    T34368750558-86-2
    RO116-9132/238 is a bioactive chemical.
    • 待询
    规格
    数量
  • RO1138452
    CAY10441
    T4436221529-58-4
    RO1138452 (CAY10441) 是一种选择性和可口服的前列环素受体拮抗剂,pKi 为8.3。它拮抗卡前列环素诱导的人神经母细胞瘤腺苷酸环化酶的激活,以剂量依赖性方式阻断环 AMP 积累,具有镇痛活性。
    • ¥ 378
    In stock
    规格
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  • Lipopolysaccharides, from E. coli O111:B4
    TSW-00811
    Lipopolysaccharides, from E. coli O111:B4 (LPS, from Escherichia coli (O111:B4)) 是一种从大肠杆菌 (E. coli O111:B4) 提取的脂多糖内毒素和TLR-4激活剂,属于S型LPS。它具有O抗原、R3型核心寡糖和脂质A的典型三部分结构。LPS通过活化免疫细胞的TLR-4而引起显著的胃部疾病,并能够诱导小鼠巨噬细胞发生M1型极化。
    • 待询
    5日内发货
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  • Biotin-Lipopolysaccharide, from E.coli O111:B4
    TSW-00909
    Biotin-Lipopolysaccharide, from E.coli O111:B4 是一种与生物素连接的 Lipopolysaccharide (LPS),能够结合链霉亲和素蛋白。Biotin-Lipopolysaccharide, from E.coli O111:B4 可用于识别 Lipopolysaccharide 配体。
    • 待询
    5日内发货
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  • Tiapamil hydrochloride
    噻帕米盐酸盐, Ro 11-1781 hydrochloride, ORE 5002 hydrochloride
    T1315457010-32-9In house
    Tiapamil hydrochloride (Ro 11-1781 hydrochloride) 是一种钙通道阻滞剂,具有抗高血压活性,可用于研究心绞痛和心血管疾病。
    • ¥ 1980 TargetMol
    In stock
    规格
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  • Mexiletine hydrochloride
    盐酸美西律, Mexiletine HCl, KOE-1173 (hydrochloride), KO1173
    T10465370-01-4
    Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂,是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流,从而降低心脏动作电位(0相)上升速率,并且降低浦肯野纤维的自律性而发挥抗心律失常作用。
    • ¥ 298
    In stock
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  • 5-Nitro-1,10-phenanthroline
    5-NP, 5-硝基-1,10-菲咯啉
    T77354199-88-6
    5-Nitro-1,10-phenanthroline (5-NP) 是一种有效的杀菌剂,可抑制艰难梭菌。
    • ¥ 247
    In stock
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  • Lipopolysaccharides, Escherichiacoli
    脂多糖 来源于大肠杆菌, Lipopolysaccharide, E. coli O111:B4
    T4107893572-42-0
    Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) 来源于大肠杆菌O111:B4, 是革兰氏阴性细菌细胞壁的一种特有成分,由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides, Escherichiacoli 有利于维持细胞外膜的完整性,保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides, Escherichiacoli 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。
    • ¥ 475
    5日内发货
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  • BIO-11006 acetate salt (901117-03-1 free base)
    BIO-11006 acetate salt
    TP1457
    BIO-11006 acetate salt (901117-03-1 free base) 是一种多糖基化富含丙氨酸的 C 激酶底物 (MARCKS) 抑制剂,类似于 MANS 肽。
    • ¥ 579
    In stock
    规格
    数量
  • 4,5-Dioxo-4,5-seco-11(13)-cadinen-12-oic acid
    T125973
    4,5-Dioxo-4,5-seco-11(13)-cadinen-12-oic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125973。
    • 待询
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  • BO 1165
    BO-1165, BO1165
    T2688189426-64-2
    BO 1165 is an monobactam antibiotic.
    • ¥ 10600
    待询
    规格
    数量
  • BO-1158
    BO1158. Antibiotic BO 1158
    T2688586455-21-2
    BO-1158 is an antibacteria agent.
    • ¥ 13900
    8-10周
    规格
    数量
  • Ro 11-3696
    Ro11-3696, Ro-11-3696
    T3434260174-20-1
    Ro 11-3696 is a bio-active chemical.
    • ¥ 10600
    待询
    规格
    数量
  • RO 116 1148
    RO-116-1148, RO 1161148
    T34343748763-84-0
    RO 116 1148 is a bioactive chemical.
    • ¥ 10600
    待询
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  • Ro 11-6893
    Ro11-6893, Ro-11-6893
    T3434466921-17-3
    Ro 11-6893 is an active bio-active chemical.
    • ¥ 10600
    待询
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    数量
  • RO-11-7330
    RO11-7330, RO-117330
    T3436964301-64-0
    RO-11-7330 is a bioactive chemical.
    • ¥ 10600
    待询
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    数量
  • Tetrahydro-11-deoxy Cortisol
    T3647268-60-0
    Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.
    5日内发货
    询价
  • Ro 1138452 hydrochloride
    T38171
    Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable. Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID:15013022 |Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. Br.J.Pharmacol. 149 110 PMID:16880763 |Bley et al (2006) RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br.J.Pharmacol. 147 335 PMID:16331286
    • ¥ 2891
    待询
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  • 1-Bromo-1,1-dichloroacetone
    T391821751-16-2
    1-Bromo-1,1-dichloroacetone, classified as a chlorine dioxide disinfection byproduct (DBP), is present in drinking water.
    • ¥ 10600
    待询
    规格
    数量
  • 4-Ethyl-2-fluoro-1,1'-biphenyl
    T6448055258-76-9
    4-Ethyl-2-fluoro-1,1'-biphenyl 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64480,CAS号为 55258-76-9。
    • 待询
    5日内发货
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  • Methanesulfonato(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II)
    T646281445085-77-7
    Methanesulfonato(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64628,CAS号为 1445085-77-7。
    • 待询
    5日内发货
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