nc1

NC1 is a novel highly active allosteric inhibitor of protein tyrosine phosphatase, non-receptor type 22 (PTPN22) which is a lymphoid-specific tyrosine phosphatase (LYP).

UNC10217938A HCl (UNC7938 HCl) 是具有寡核苷酸 (oligonucleotides) 增强作用的 3-deazapteridine 类似物， 通过调节寡核苷酸在细胞内的运输和从内体中的释放来增强寡核苷酸的作用。UNC10217938A HCl 还增强了 siRN 和反义寡核苷酸的作用。

ONC1-13B 是一种高效的雄激素受体（AR）拮抗剂，对雄激素敏感的人 PCa LNCaP 细胞中抑制 PSA 产生的ic50在 59-80 nM范围内。

(S)-Desmethyl-NNC112 ((+)-Desmethyl-NNC112) 是一种选择性 PET 放射性配体，可与 D-多巴胺受体结合。

ZINC12409120 (R-4584) 是一种具有选择性的 ERK 抑制剂。ZINC12409120 对ERK具有抑制作用，IC50 为 5.0 μM。ZINC12409120 通过干扰 FGF23:α-Klotho 的相互作用而抑制 ERK 活性。

UNC1999 是一种可口服的，选择性和 SAM-竞争性的 EZH2和 EZH1抑制剂，IC50分别为 <10 nM 和 45 nM。

ZINC194100678是一种有效的PAK1抑制剂，IC50值为8.37μM 。ZINC194100678 具有较强的抗增殖活性，对MDA-MB-231的IC50值为40.16μM。ZINC194100678可用于癌症的研究。

UNC1079 是选择性 L3MBTL3 结构域抑制剂，也是UNC1021的哌啶类似物，结构相似，但具有较低的抑制作用。

UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.

ZINC13466751 是有效的 HIF-1α von Hippel-Lindau 相互作用抑制剂，抑制作用的 IC50为 2.0 µM。

BNC105 是一种微管蛋白聚合抑制剂，具有抗增殖和破坏肿瘤血管的特性。

UNC10099984A (Compound 6) 是一种针对多巴胺 D2受体的功能选择性配体，显示出 Ki值 4.6 nM 和对β-arrestin的 EC50 值为 6.2 nM。此化合物适用于研究与 D2 受体相关的中枢神经系统疾病。

UNC10142 (Compound 44) 是一种针对CHD1的小分子拮抗剂，其结合的IC50值为1.7 μM。UNC10142 对PTEN缺陷的前列腺癌细胞显示出剂量依赖性活性降低。

UNC1215 是一种选择性 L3MBTL3甲基赖氨酸结构域的拮抗剂，IC50为40 nM，Kd 为 120 nM。它可研究恶性脑瘤。

ZINC17167211 is a selective peroxisome proliferator-activated receptors-α agonist.

NC1153 is a blocker of IL-2-induced activation of JAK3 and its downstream substrates STAT5a b. It promotes long-term allograft survival and sparing the recipient from multiple toxicities.

NC182 is a topo II inhibitor that shows selective and potent topo II inhibition on the induction of topo II-dependent DNA fragmentation.

NC190 is an inhibitor of topoisomerase II that inhibited the growth of FM3A cells in clinical trials. NC-190 strongly inhibited the growth of FM3A cells when cultured with NC-190 for 48 h (IC50: 0.019 μg ml). NC-190 potently suppressed DNA synthesis with

UNC10201652 是一种 L1 特异性肠道细菌 β-葡萄糖醛酸酶 (GUSs) 的有效抑制剂，能够作用于大肠杆菌 (E. coli) (IC50: 0.117 μM)。UNC10201652 只有在粪便肠道菌群 L1 GUS 酶高度丰富的个体中才可以阻断 SN-38 glucuronide 的加工。

BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.

UNC10112785 is a novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures.

UNC1666 is a dual ATP-competitive small molecule tyrosine kinase inhibitor, which potently diminishes Mer and Flt3 phosphorylation in AML.

UNC10245380 作为一种CIB1抑制剂,具有 8 μM的IC50值.该化合物还能够抑制AKT与ERK的磷酸化,并能增强TRAIL-R1 D5的表达.通过这些作用,UNC10245380 能特异性地杀死依赖CIB1的癌细胞,显示出其在CIB1探针开发及癌症研究方面的应用潜力.

Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂，具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制，常用于 2 型糖尿病的研究。