isg15

Expression system: E. coli
Length: 1-154, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 2-157, Full Length of Mature Protein
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-155, Full Length of Mature Protein
Activity: Not Tested

Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha beta stimulation or microbial challenge. The functions or biochemical consequences ISG15 conjugation to proteins are not yet known, but it appears that this modification does not target proteins for proteasomal degradation. ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. Upon interferon treatment, ISG15 can be detected in both free and conjugated forms, and is secreted from monocytes and lymphocytes where it can function as a cytokine. In the cell, ISG15 co-localizes with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.

ISG15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.9 kDa and the accession number is AAH09507.1.

ISG15 Protein, Human, Recombinant (mature form) is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is AAH09507.1.

Expression system: E. coli
Length: 1-372, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 22-208, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-281, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-314, Partial
Activity: Not Tested

The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro papain-like protease Protein (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 36.91 kDa and the accession number is AAX16193.1.

Expression system: E. coli
Length: 1-153, Full Length
Activity: Not Tested