hypoglycemia

Gatifloxacin (CG5501) 是一种具有广谱抗菌活性的氟喹诺酮类抗生素。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg ml) 和细菌 II 型拓扑异构酶(IC50=13.8 μg ml)。在动物模型中，它有抗细菌性结膜炎作用。

Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种氟喹诺酮类抗生素，有广谱抗菌活性。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg ml)和细菌 II 型拓扑异构酶(IC50=13.8 μg ml) 。它在动物模型中，可研究细菌性结膜炎。

AZD-1656 是口服有效的葡萄糖激酶选择性激活剂，EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。

Bruceine E 是从 B. javanica 种子中分离得到的，具有降血糖作用。 Bruceine E 可用于作为胰岛素促分泌剂的研究。

PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4  μM)。 PF-04937319 保持降糖功效，同时降低许多其他 GKA 观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。

Risarestat (CT-112)是一种有效的醛糖还原酶抑制剂和甲状腺激素受体 （TR） 拮抗剂，可用于治疗低血糖症。

Sari 59-801 是具有口服活性的降血糖化合物，能够降低几个物种的血糖，且可以提高大鼠和小鼠的血浆中胰岛素水平。

CP-316819 (GPi 819) 是一种高效的糖原磷酸化酶 (GPase) 抑制剂，具有降血糖作用，抑制 huSMGPa 和 huLGPa，可在低血糖期间维持神经元活性，可用于研究高血糖。

Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has exhibited anticancer activity.

AZD-6370 is a glucokinase activator. AZD-6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. AZD-6370 do not affect the central counterregulatory response to hypoglycemia

BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial a

Ketomethine is a combination of methionine, cobaltous bichloride, and propylene glycol and can be used for the treatment of hypoglycemia in animals.

Sodium ethyl oxalacetate can be used in the treatment of hypoglycemia and ketonemia in the ruminant.

Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.3,4 |1. Mallatou, H., Pappa, E., and Massouras, T. Changes in free fatty acids during ripening of Teleme cheese made with ewes', goats', cows' or a mixture of ewes' and goats' milk. Int. Dairy J. 13(1-3), 211-219 (2003).|2. Hyang, C.B., Alimova, Y., Myers, T.M., et al. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. Arch. Oral Biol. 56(7), 650-654 (2011).|3. Onkenhout, W., Venizelos, V., van der Poel, P.F.H., et al. Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disorders. Clin. Chem. 41(10), 1467-1474 (1995).|4. Rinaldo, P., O'Shea, J.J., Coates, P.M., et al. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. N. Engl. J. Med. 319(20), 1308-1313 (1988).

KQMEEEAVRLFIEWLKNGGPSSGAPPPS is a Exendin-4 peptide derivative. Exendin-4 is a pure GLP-1 receptor agonist. Exendin-4 peptide derivatives are structurally derived from Exendin-4 and may relates to dual GLP-1 glucagon receptor agonists. Their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake. These dual GLP-1 glucagon receptor agonists show reduced activity on the GIP receptor to reduce the risk of hypoglycemia[1]. [1]. US20150315260 A1

Paulownin 是药用植物的成分，是泡桐木的成分。

Volagidemab (AMG-477) 是一种胰高血糖素受体 (GCGR) 拮抗剂，也是一种单克隆抗体，可用于研究1型糖尿病 (T1D) 和低血糖等内分泌与代谢疾病。

Dasiglucagon是一种稳定的人胰高血糖素肽类似物，用于治疗严重低血糖，具有快速且有效的特点。

dasiglucagon acetate 是一种用于糖尿病低血糖治疗的新型胰高血糖素类似物。 它已证明在水性制剂中的溶解度和稳定性。药代动力学研究表明，与传统的重组胰高血糖素相比，它的胰高血糖素具有更高的吸收率和更长的血浆消除半衰期。

Serpentine 是一种玫瑰花根中的生物碱，可用作胰岛素增敏剂，以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化，从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达，从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食 链脲佐菌素（HFD STZ）诱导的糖尿病小鼠中，Serpentine 显著延长了胰岛素的降血糖时间，显著降低了外源性胰岛素的使用，抑制了内源性胰岛素的分泌。

Avexitide acetate (exendin 9-39）是一种有效的胰高血糖素样肽 1 受体 (GLP-1R) 拮抗剂，可用于研究肥胖后低血糖。

GHRF, ovine是一种生长激素释放因子。GHRF是低血糖对垂体生长激素(GH)释放影响的特异性中介因子。