hatu

HATU 是一种用于肽偶联化学的试剂，用于从羧酸生成活性酯。 HATU 与 Hünig 碱（N,N-二异丙基乙胺，DIPEA）一起使用以形成酰胺键。

7-methyl-8-oxononanoic acid is an intermidate for synthesis of conjugated molecules. The acid group can derivatize amine-containing molecules in the presence of activators such as EDC or HATU.

Benzyloxy carbonyl-PEG4-acid is a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines with the help of activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis.

Fmoc-9-aminononanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

14-(Fmoc-amino)-tetradecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. 14-(Fmoc-amino)-tetradecanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

10-Oxononadecanedioic acid is a long alkane linker with two terminal carboxylic acid groups. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

N-Boc-15-aminopentadecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Fmoc-11-aminoundecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applicaitons. Fmoc-11-aminoundecanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Fmoc-ε-Acp-OH can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-ε-Acp-OH is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Boc-7-Aminoheptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applicaitons. Boc-7-Aminoheptanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Boc-8-aoc-oh can be used as a PROTAC linker in the synthesis of PROTACs. Boc-8-aoc-oh is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Fmoc-12-aminododecanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Fmoc-7-amino-heptanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Fmoc-5-aminopentanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Fmoc-4-aminobutanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-4-aminobutanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

DBCO-PEG24-acid 是一种独特的点击化学试剂,作为带有 PEG 连接子的 DBCO-acid 的衍生物,并含有 DBCO 基团.这种 DBCO 基团因其高能量的应变促进特性,常被用于无铜点击化学反应.其亲水性的聚乙二醇链增强了水溶性.此外,该化合物的末端羧酸可在 EDC 或 HATU 等激活剂存在下与伯胺基团反应,形成稳定的酰胺键.产品为试剂级,仅限研究使用.

Sulfo DBCO-PEG3-acid 是一种具备叠氮基团的点化学试剂,是DBCO-acid的衍生物,它包含了一个PEG连接剂和DBCO基团.DBCO基团以其应变促进的高能量特性,经常被应用于无铜点击化学反应中.其亲水性的聚乙二醇链和硫基极大地提高了其水溶性.该化合物的末端羧酸在激活剂(如 EDC 或 HATU)存在下能与伯胺基团发生反应,生成酰胺键.该产品为试剂级,仅限研究使用.

Methyltetrazine-amido-N-bis(PEG4-acid) 为含甲基四氮基的高效点击化学试剂.该化合物含 Tetrazine 基团和双羧酸端基,属于 PEG 衍生物,可在不需要 Cu 催化及高温条件下与含 TCO 的生物分子进行反应,通过 Diels-Alder 环加成反应(即逆电子需求 Diels-Alder 反应,iEDDA)迅速形成稳定共价键.此种反应速度快,选择性高.另外,末端羧酸可在激活剂(如 EDC 或 HATU)存在下与伯胺反应,形成酰胺键.PEG 连接增强了其在水中的溶解性.本品为试剂级,仅限研究使用.

Stearic acid-PEG-CH2CO2H (MW 1000) 是一种两亲性 PEG 聚合物，能在水溶液中形成胶束，适用于药物递送纳米颗粒。其末端羧基在 HATU EDC 活化剂存在下，通过缩合反应可与胺发生反应。仅限于试剂级研究使用。

Stearic acid-PEG-CH2CO2H (MW 3400) 是一种亲脂性硫醇反应性PEG聚合物。硬脂酸部分用于包封疏水性治疗剂，而PEG链提高整体水溶性及生物相容性。在活化剂（如HATU或EDC）存在下，羧酸（-COOH）与胺（-NH2）通过缩合产生稳定的酰胺键。试剂级，仅供研究使用。