dc-4

DC4 can be used to synthesize antibody-drug conjugate (ADC), which is an ADC cytotoxin. DC4 can be used for targeted therapy of tumors.

DC4 crosslinker, an 18Å mass spectrometry-cleavable crosslinking reagent, features two intrinsic positive charges facilitating the fragmentation of cross-linked peptides into their constituent peptides through collision-induced dissociation or in-source decay. Initial fragmentation leads to cleavage adjacent to the positive charges, enabling the identification of cross-linked peptides as pairs of ions with precise mass separation. Furthermore, the resultant intact peptide fragments can undergo further fragmentation, producing a sequence of b- and y-ions for peptide identification.

DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used for targeted treatment of cancer.

DC41 is a derivative of DC1. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylating agents, used for targeted treatment of cancer.

The IC50 of DC44SMe for Ramos, Namalwa and HL60 / s cancer cells was 2.0 nM, 2.8 nM and 1.9 nM, respectively. DC44SMe can be used for targeted treatment of cancer. DC44SMe is a phosphate prodrug of DC44 and can be used in the synthesis of antibody-drug co

The IC50s of DC4SMe on Ramos, Namalwa and HL60 / s cancer cells were 1.9 nM, 2.9 nM and 1.8 nM, respectively. DC4SMe can be used for targeted therapy of tumors. DC4SMe is a phosphate prodrug of the cytotoxic DNA alkylating agent DC4 and can be used in the

NMS873 是一种有效的选择性变构 VCP/p97 抑制剂，IC50值为 30 nM。

DBEQ (JRF 12) 是一种选择性的，ATP 竞争性p97抑制剂，对 p97(wt) 和 p97(C522A) 的IC50值分别为 1.5 μM 和 1.6 μM，也可抑制Vps4，IC50值为 11.5 μM。

MLS-573151 是 GTPase Cdc42 的选择性抑制剂，EC50 为 2 μM。它通过阻止 GTP 与 Cdc42 的结合来发挥作用。

EHop-016 是一种特异性 Rac GTPase 抑制剂，对 MDA-MB-231 和 MDA-MB-435 细胞中的 Rac1 的 IC50 为 1.1 μM，也可抑制Rac3 。它还抑制 Vav2 与 Rac，Rac 激活的 PAK1 相互作用，片状脂蛋白形成和细胞迁移。

ML141 (CID-2950007) 是一种高效变构，选择性可逆的 Cdc42 GTPase 非竞争性抑制剂，IC50值为200 nM。它抑制 Cdc42 野生型和 Cdc42 Q61L 突变体。

GNF-7 是一种多重激酶抑制剂。它对ACK1和GCK 具有抑制活性，IC50分别为 25 nM 和 8 nM。它是一种 Bcr-Abl 的抑制剂，对 Bcr-AblWT 和 Bcr-AblT315I 作用的IC50值分别为 133 nM 和 61 nM。它可用于研究血液恶性肿瘤。

Palmitic acid-1,2,3,4-13C4 is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid (T2908) is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids,respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellular proteins,promotes protein-vesicle interactions,and regulates various G protein-coupled receptor functions.1Red blood cell palmitic acid levels are increased in patients with metabolic syndrome compared to patients without metabolic syndrome and are also increased in the plasma of patients with type 2 diabetes compared to individuals without diabetes.3,4

CASIN (Pirl1-related Compound 2) 是选择性GTPase Cdc42抑制剂，IC50值是 2 uM。

DC432是一种细胞内可渗透的肽类抑制剂，针对N-末端Xaa-Pro-Lys N-甲基转移酶1 (NTMT1; IC50 = 0.054 µM)。该化合物与NTMT1和NTMT2有结合作用（Kds分别为0.3和1 µM），并在10和50 µM的浓度下，通过细胞外实验抑制NTMT1对调节染色体凝缩1 (RCC1) N-末端二甲基化。DC432（100 µM）在HCT116细胞中减少了RCC1 SPKRIA基序的三甲基化。

DC 432是一种强效的N-terminal methyltransferase 1/2 (NTMT1/2) (IC50= 54 nM)肽模拟抑制剂，含有BM30肽和额外五个精氨酸残基。在HCT116细胞中，DC 432处理能够降低调节染色体凝缩1和SET蛋白的N端甲基化水平。该化合物具有细胞渗透性。

Isochlorogenic acid C 4'-O-glucoside 是一种天然化合物，可作为天然产物对照品。

CBDB, a phytocannabinoid analytical reference standard, is identified in strains of Cannabis and hemp. It is regarded as an impurity in commercial cannabidiol (CBD) extractions from hemp. This compound is designated for research and forensic applications.

Diethyl bipy55'DC inhibits CP4H activity in cultured cells. The stability of collagen relies on post-translational modifications, the most prevalent being the hydroxylation of collagen strands by collagen prolyl 4-hydroxylases.

DC-159a 是一类具有广谱抗菌活性的 8-甲氧基氟喹诺酮，尤其对革兰氏阳性细菌有效。其对消化链球菌属、艰难梭菌和脆弱拟杆菌的 MIC90 分别为 0.5、4 和 2 μg/mL。

CCL-34 是一种 Toll 样受体 4 (TLR4) 的激活剂。CCL-34 能以剂量依赖性的方式显著诱导树突状细胞 (DC) 的 CD83 表达和 IL-12p70 的产生，从而促进 DC 的成熟。该化合物增强了 DC 对幼稚 CD4+CD45+RA+ T 细胞的增殖及其 IFN-γ 分泌的同种刺激活性。此外，CCL-34 还能进一步诱导接种阿霉素处理过的结直肠癌细胞的小鼠的抗原呈递能力。CCL-34 可用于免疫刺激的相关研究。

5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.

5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.

5'-O-DMT-N4-Bz-5-Me-dC (DMT-NBZ-5-METHYL DC) 是一种修饰的核苷，可用于合成核苷磷酰胺。