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CU-CPD107是一种 toll-like receptor 8 （TLR8）的选择性激动剂，对ssRNA 配体也表现出激活活性。在R848存在的情况下，CU-CPD107是TLR8信号抑制剂 (IC50=13.7 μM)。在ssRNA 存在的情况下，CU-CPD107表现出协同激动剂活性，而CU-CPD107单独不影响TLR8信号转导。

EML631 is a potent and selective SPIN1 inhibitor (SPIN1 Kd= 3 microM).

CU-115 是一种有效的，选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。THP-1 细胞中，CU-115 减少了 R-848 激活的 TNF-α 和 IL-1β 的产生。

Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。

Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。

Temocapil 是一种酪氨酸激酶抑制剂。

CU-T12-9 是特异性 TLR1 2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1 2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。

CU-CPT-9a 是TLR8特异性拮抗剂，IC50值为 0.5 nM。

CU-CPT17e 是多Toll 样受体激动剂，可激活TLR3、TLR8和TLR9。

CU-CPT22 是 toll 样受体 1 和 2 蛋白复合物抑制剂，可阻断 Pam3CSK4诱导的 TLR1 2 激活，IC50值为 0.58 µM。 它与 TLR1 2 结合的合成三酰脂蛋白竞争，Ki 值为 0.41 µM。

FA4-Cu 是由有效的胰腺癌抑制剂 FA4 与 Cu(II) 形成的复合物，能够通过 ER 和线粒体应激诱导细胞凋亡 (apoptosis)。

TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3 dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。

CU-3 is a potent and selective inhibitor of diacylglycerol kinase alpha (DGKalpha). CU-3 attenuates cancer cell proliferation and simultaneously enhances immune responses including anti-cancer immunity.

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)

Cu (II) Protoporphyrin IX functions as a negative control for Zn (II) Protoporphyrin, a heme oxygenase inhibitor. Heme oxygenase is involved in tumor cell resistance to chemotherapy and the regulation of free radical formation, inflammation, and vascular repair.

CuATSP是有效的自由基捕获抗氧化剂 (RTA)和铁死亡抑制剂，在双（硫代氨基脲）配体上可逆地添加一个过氧自由基来抑制脂质过氧化，对肌萎缩性侧索硬化症（ALS）和帕金森病等疾病有治疗前景。

Cu(II)GTSM是一种细胞通透性铜复合物，能够显著抑制GSK3β的活性，并抑制神经毒性的淀粉样β三聚体和磷酸化tau的水平，能够逆转阿尔茨海默病小鼠的认知缺陷。

Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。

CU-6PM is a new fluorescent RXR agonist. CU-6PMN was designed based on the fact that umbelliferone emits strong fluorescence in a hydrophilic environment, but the fluorescence intensity decreases in hydrophobic environments such as the interior of proteins. The developed assay CU-6PMN enabled screening of rexinoids to be performed easily within a few hours by monitoring changes of fluorescence intensity with widely available fluorescence microplate readers, without the need for processes such as filtration.

AqB007 is a selective blocker of the Aquaporin-1 ion channel conductance, thereby slowing cancer cell migration.

CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model.

CU239 is a selective non-retinoid inhibitor of RPE65 which suppresses visual cycle and prevents retinal degeneration.

SA09-Cu是一种NDM-1的非竞争性抑制剂，具有9.6 nM的IC50。该化合物通过作用于氧化酶的Zn(II)-硫醇盐位点，能将NDM-1转化为无活性形态，从而抵御细菌细胞内的硫醇还原作用。SA09-Cu对于多种产生NDM-1的肠杆菌科碳青霉烯耐药菌株（CRE）表现出明显的抑制作用，有效恢复了美罗培南的活性，并有助于减缓碳青霉烯耐药性的进展。