asymmetric

UCB-9260 是口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其Kd 值为 13 nM。

Asymmetric dimethylarginine 是内源性一氧化氮合成酶抑制剂，可以作为内皮功能障碍的标志。

Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7 cyclin H Mat1 and Cdk9 cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibulocydine rapidly blocked phosphorylation of the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II, a process mediated by Cdk7 9. Anti-apoptotic gene products such as Mcl-1, survivin, and X-linked IAP (XIAP) are crucial for the survival of many cell types, including HCC. Following the inhibition of RNA polymerase II phosphorylation, ibulocydine caused rapid down-regulation of Mcl-1, survivin, and XIAP, thus inducing apoptosis. Furthermore, ibulocydine effectively ind......

Dimethylamine hydrochloride (N,N-Dimethylamine) 大量存在于人类尿液中。

D-Lysine(D-赖氨酸)是L-Lysine的 D 型异构体，可通过L-赖氨酸的化学消旋和微生物不对称降解制备。D-Lysine可减少放射性标记肽在肾脏的摄取，降低肾毒性。

7-Methoxy-1-naphthaleneacetic acid 是植物生长素作用的抑制剂。 7-Methoxy-1-naphthaleneacetic acid 抑制与拟南芥和玉米中生长素不对称分布相关的极性生长素转运和热带反应。 7-Methoxy-1-naphthaleneacetic acid 抑制由酵母中表达的 AUX1、PIN 和 ABCB 蛋白介导的生长素转运。

Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) 是铜催化的不对称迈克尔反应的辅助剂。

MBS Crosslinker (MBS protein crosslinker) 是一种交联剂，可用作不对称间隔基。

Epoxide hydrolase是一种酶，其作用是催化环氧化物与水的反应，实现环氧基团转化为二醇。该酶在处理环境污染物、脂质代谢、解毒、炎症反应、以及心脑血管系统健康调控等方面扮演着关键角色。Epoxide hydrolase也被应用于不对称催化反应，特别是在环氧化物的不对称开环反应中，广泛用于手性药物分子的制备。

C-MS023是一种光激活的MS023前药，用于时空抑制组蛋白精氨酸不对称二甲基化 (Histone Arginine Asymmetric Dimethylation)。它能抑制PRMT6介导的H3不对称二甲基化氨酸2 (H3R2me2a)，其IC50约为0.2224 μM。在420 nm可见光照射下，C-MS023的光解释放MS023，从而有效下调组蛋白精氨酸不对称二甲基化及与DNA复制相关的转录组活性。

IMM-01 是一类新型的哺乳动物透明 (mDia) 相关形式的小分子激动剂，其作用于 Rho GTPase 下游以组装肌动蛋白丝，并与微丝组织在迁移和不对称分裂过程中建立和维持细胞极性. GTP 结合的 Rho 通过破坏 DID 和 DAD 自动调节结构域之间的相互作用来激活 mDia 家族成员，从而释放 FH2 结构域以调节肌动蛋白和微管动力学。

Nb-enantride is a novel chiral trialkylborohydride for the asymmetric reduction of ketones.

L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitorsBioorg. Med. Chem. Lett.24(1)61-64(2014)

Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC50 = 0.8 μM) Negative control SGC 6870N (Cat. No. 7184) also available.

1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride，又称PAC，是一种环胺，通常用作不对称合成中的手性助剂，包括Diels-Alder 反应、羟醛反应和Michael 加成。

UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.

UCB-6786 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins.

HBED-CC-tris(tert-butyl ester)是HBED-CC的一种单价变体，可用于合成基于非对称 HBED-CC 的放射性化合物，可用于肿瘤成像。

Alnuctamab (EM901)为一种不对称双臂人源化IgG T细胞接合器，主要应用于免疫学研究。

(–)-G-lactone, a bicyclic γ-lactone, serves as a chiral synthon for prostaglandin and a building block. It is formed through an asymmetric Baeyer-Villiger oxidation reaction. Additionally, (–)-G-lactone has been utilized in the synthesis of HIV-1 protease inhibitors.

(R)-Methyl 3-hydroxybutanoate 是一种对映异构体，其特征是甲基 (-CH3) 基团的第三个碳原子上羟基 (-OH) 基团向右构型。它呈无色透明液体，能溶解于乙醇和乙醚等有机溶剂，但不溶于水。通常，该化合物作为合成各种有机化合物的结构单元，包括药物、农用化学品和调味剂。此外，它还广泛用作不对称合成反应中的手性助剂，这类反应通过立体选择性方式形成化学键。

7-Isopentenyloxy-gamma-fagarine has highly cytotoxicity against the MCF-7and Jurkat cell line. It has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine and evodine.

TsDPEN (Compound 2) 是一种生化试剂，其衍生物包含 N,N,N 亚胺的手性配体，能够用于铜催化的不对称 Kinugasa 反应。

Inhoffen Lythgoe diol 是一种有机分子，广泛用于有机合成中的手性选择性反应，能够作为催化剂和配体。在制备含氮、含硫天然产物以及药物和材料科学的研究中，它有广泛的应用。虽然没有直接医学用途，但其在不对称合成中和许多重要化学品的生产研究中具有重要地位。