AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Generated by a family of diadenylate cyclases, c-di-AMP can impact bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions. Bacteria-derived cyclic dinucleotides, including c-di-AMP, trigger the expression of interferon genes in mammalian cells.
AMP-PNP tetralithium(Adenylyl-imidodiphosphate tetralithium)是一种不可水解的 ATP 类似物,可完全占据 ATP 结合位点而不发生酶促水解,从而为解析 ATP 依赖性生物过程提供稳定且可控的实验条件。AMP-PNP 广泛用于研究酶活性、激酶调控、DNA 和 RNA 代谢、离子通道功能以及蛋白复合体组装等生化和结构生物学研究。