alpha-glucosidase

α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate. It plays a vital role in facilitating glucose absorption by the small intestine. Inhibiting α-Glucosidase effectively manages non-insulin-dependent diabetes mellitus (NIDDM).

Acarbose (BAY g 5421) 是一种具有口服具有活力 α-葡萄糖苷酶 (alpha-glucosidase) 抑制剂 (IC50=11 nM)，是一种降糖药。它能提高磺脲类药物或胰岛素的降血糖作用。

α-Glucosidase-IN-23 是具有口服活性的 α-Glucosidase 抑制剂。α-Glucosidase-IN-23 通过抑制 a-glucosidase 降低血糖 (IC50= 4.48 μM)。α-Glucosidase-IN-23 可用于糖尿病的研究。

Miglitol (BAY1099) 是一种口服抗糖尿病化合物，能够抑制糖复合体分解为葡萄糖。

CQ is a potent inhibitor of alpha-glucosidase

Torachrysone-8-O-b-D-glucoside 可从 Polygonum multiflorum 分离得到。它对 DPCs(真皮乳头细胞)的增殖具有促进作用。

α-Glucosidase-IN-22是一种α-葡萄糖苷酶选择性抑制剂（IC50=0.64 μM）。α-Glucosidase-IN-22有抗糖尿病的活性，在2型糖尿病(T2DM)研究中具有潜力。

Ceftezole is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. It is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria.

Glycovir（亦称SC-49483）是一种针对HIV的前药。它作为alpha-glucosidase-1抑制剂，是针对宿主细胞内质网中病毒糖蛋白加工的候选抗HIV化合物。

Homonojirimycin is an alpha-glucosidase inhibitor.

1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂，具有降血糖、减肥和抗病毒的作用，可抑制餐后血糖，预防糖尿病。

Acarbose sulfate is an anti-diabetic drug and is an inhibitor of alpha-glucosidase.

Nopol is an inhibitor of alpha-glucosidase.

Betulinaldehyde (Betunal) 是五环三萜，有抗金黄色葡萄球菌等细菌和真菌作用。

Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) 是一种天然化合物，广泛存在于蔬菜和水稻中，经消化后可在肠道菌群中代谢。

Anti-hyperglycemic agent 1 是一种 α- 葡萄糖苷酶 (α-Glucosidase) 的有效抑制剂 (IC50: 0.53 μM)。Anti-hyperglycemic agent 1 能够用于研究糖尿病。

α-Glucosidase-IN-19 (Compound 6B) 是一种口服具有活力的 α-glucosidase 抑制剂 (IC50: 3.63 μM)，具有抗糖尿病作用。

Salacinol is a naturally occurring alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata.

SP-187, also known as N-9-DNJ and UV-4B, is an alpha-Glucosidase inhibitor potentially for the treatment of dengue fever and influenza infection. Proline-producing strains of Serratia marcescens were more osmotolerant than wild-type strains. Growth inhibition by proline analogs was significantly enhanced by increasing the osmotic stress of the medium.

Valienamine为α-葡萄糖苷酶抑制剂，为众多天然糖苷酶抑制剂，包含用于作物保护的validamycin A及治疗糖尿病的阿卡波糖，的关键活性成分。

Clervonafusp alfa (VAL-1221) 作为一种融合蛋白，针对胞浆及溶酶体糖原进行靶向。该化合物结合了穿透细胞的抗体Fab部分与重组人酸性葡萄糖苷酶 (rhGAA)，通过核苷转运体ENT-2进入细胞质，再利用甘露糖-6-磷酸受体(M6PRs)导向溶酶体。主要应用于晚发型庞贝病的研究领域。

Ceftezole sodium (Falomesin) 是一种广谱 cephem 抗生素，具有抑制多种革兰氏阳性菌和革兰氏阴性菌活性。它是一种α-葡萄糖苷酶抑制剂，具有体内抗糖尿病活性。

15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.

Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).