acidic-ph

4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) 是 4-硝基苯基 (pNP) 糖吡喃糖苷的人工底物，可用于 α-半乳糖苷酶活性的检测。它用作底物能够显著增加 pNP 的释放量。

Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂，是一种取代的苯并咪唑，是H+ K+-ATPase 抑制剂，IC50为 6.8 μM。它可以改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。

Finafloxacin, a fluoroquinolone antimicrobial agent from a new 8-cyano subclass, is most effective in slightly acidic environments (pH 5.0-6.0), a condition where other fluoroquinolones typically reduce in activity. It selectively targets bacterial type II topoisomerases, such as DNA gyrase and DNA topoisomerase IV, making it suitable for treating serious bacterial infections particularly in acidic contexts, including urinary tract infections (UTIs) and Helicobacter pylori infections.

Trepibutone 是一种酸性药物，具有不依赖于 pH 值的释放能力。

JK-2 is a hydrogen sulfide (H2S) donor. At acidic pH, it shows a greatly accelerated H2S release upon protonation-induced intramolecular cyclization.

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10563 is a member of a new class of S-nitrosothiol species that act as an NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 59% and 16% at pH 6.0 and 7.4, respectively.

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10564 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 59% and 16% at pH 6.0 and 7.4, respectively.

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10565 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of 130 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 71% and 44% at pH 6.0 and 7.4, respectively.

Acid phosphatase(酸性磷酸酶)是一种在消化过程中从其他分子中释放附着的磷酸基的酶，储存在溶酶体中，具有最佳的酸性pH值，可作为医学标志物和癌症免疫治疗的靶点。

Methyl yellow（Solvent Yellow 2）为pH指示剂，该化合物在pH低于4.0时显红色，高于4.0时转为黄色。

Bromothymol Blue sodium salt 作为pH指示剂，在测量弱酸与弱碱时常用。该指示剂在酸性条件下表现为黄色，在碱性条件下变为蓝色。

PD-1 PD-L1-IN-47 (MolPort-001-742-690) 作为一种选择性PD-1 PD-L1信号通路抑制剂,在酸性环境中对PD-L1展现出较高的亲和性,并且具有较低的毒性.该化合物主要应用于肿瘤相关的研究领域.

1O14 是一种可电离脂质。在酸性 pH 条件下，1O14 能形成不稳定的非双层结构，这是内体逃逸和RNA 细胞溶胶递送的关键。1O14 还可用于制备脂质体。

IAJD93 是一种可电离脂质，其在酸性 pH 下形成不稳定非双层结构的能力对于内体逃逸和 RNA 细胞溶胶递送至关重要。IAJD93 可用于脂质体的制备。

IAJD249 是一种可电离脂质。此类脂质在酸性 pH 下具备形成不稳定非双层结构的能力，这对于内体逃逸和 RNA 递送至细胞溶胶至关重要。IAJD249 可以用于脂质体的制备。

Al-28 是一种可电离脂质，在酸性 pH 条件下能够形成不稳定的非双层结构，这对内体逃逸和 RNA 细胞溶胶递送至关重要。Al-28 可用于制备脂质体。

L16 是一种可电离脂质。在酸性 pH 条件下，其形成不稳定的非双层结构的特性对于内体逃逸和 RNA 递送至细胞溶胶至关重要。L16 可用于脂质体的制备。

306Oi9-cis2 是一种可电离脂质，其在酸性 pH 下能形成不稳定的非双层结构，这对内体逃逸和 RNA 细胞溶胶递送至关重要。306Oi9-cis2 可用于脂质体的制备。

RM 137-15 是一种可电离脂质，其在酸性 pH 下具有形成不稳定非双层结构的能力，这在内体逃逸和 RNA 在细胞溶胶中的递送过程中起关键作用。RM 137-15 还可用于脂质体的制备。

LH2 peptide 是一种具有细胞穿透性的 pH 响应性肽二聚体，其氨基酸序列为 LHHLCHLLHHLCHLAG。在弱酸性环境（如肿瘤微环境）中，由于组氨酸残基的质子化 (pKa约为 6)，该多肽可以增强肿瘤细胞内摄取。将 LH2 peptide 与抗癌剂紫杉醇共轭形成的复合物 PTX-LH2，在皮下乳腺肿瘤模型中表现出比单独使用紫杉醇更强的肿瘤抑制效果。LH2 peptide 有潜力成为抗癌研究中的递送载体。

Sodium sesquicarbonate hydrate是一种具有缓冲剂活性的化合物，通过中和酸性物质来保持pH值稳定，而不会引起pH值的突然变化。这一特性使其广泛应用于各个领域，尤其在维持生物体内的酸碱平衡方面效果显著。