| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T13510 | Sigma-LIGAND-1 | Sigma receptor | GPCR/G Protein |
| Sigma-LIGAND-1 是一种选择性 sigma 受体配体，在 DTG 和 PPP 位点的 IC50 分别为 16 nM，19 nM。Sigma-LIGAND-1 对多巴胺 D2 受体的 Ki 为 4000 nM。 | |||
| T63048 | Sigma-LIGAND-1 hydrochloride | ||
| Sigma-LIGAND-1 hydrochloride 是一种选择性 sigma 受体配体，能够作用于 DTG (IC50: 16 nM) 和 PPP (IC50: 19 nM) 位点。Sigma-LIGAND-1 hydrochloride 能够作用于多巴胺 D2受体 (Ki: 4000 nM)。 | |||
| T39211 | PD 144418 oxalate | Sigma receptor | GPCR/G Protein |
| PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity. | |||
| T50090 | 3-(2-phenylethynyl)pyridine | Others | Others |
| 3-(2-phenylethynyl)pyridine 是一种吡啶衍生物，是人体中各种受体的配体，包括多巴胺 D2受体、sigma-1受体和5-HT6受体，已被研究用于治疗各种神经疾病，包括精神分裂症、抑郁症和阿尔茨海默病。 | |||
| T1186L |
Ifenprodil
RC-61-91,RC 6191,RC 61-91,RC61-91,艾芬地尔 |
NMDAR; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
| Ifenprodil 是 NMDA 受体抑制剂，特别是 GluN1（甘氨酸结合 NMDA 受体亚基 1）和 GluN2B（谷氨酸结合 NMDA 受体亚基 2）亚基的抑制剂。此外，它抑制 GIRK 通道并与 α1 肾上腺素能、血清素和 sigma 受体相互作用。 | |||
| T25584 |
KSCM-1
KSCM 1 |
||
| KSCM-1 is a selective sigma-1 receptor ligand. | |||
| T26100 |
RLH 033
RLH033,RLH-033 |
||
| RLH 033 is a selective ligand for the sigma 1 recognition site. | |||
| T61846 | CM398 | ||
| CM398 is an orally active chemical compound that acts as a highly selective ligand for the sigma-2 receptor (K i =0.43 nM), demonstrating a significant ratio of selectivity between sigma-1 and sigma-2 receptors (1000-fold). Moreover, CM398 exhibits notable affinity towards dopamine (K i =32.90 nM) and serotonin transporters (K i =244.2 nM). In addition, CM398 has shown promising efficacy as an anti-inflammatory analgesic in a mouse model of inflammatory pain induced by formalin [1]. | |||
| T16445 | PD 144418 | Sigma receptor | GPCR/G Protein |
| PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significant affinity for other receptors, ion | |||
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