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33

抑制剂 & 化合物

38

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T75174	Anti-inflammatory agent 42	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Anti-inflammatory agent 42 具有抗炎活性，抑制 LPS 刺激的巨噬细胞 TNF-α 和 IL-6 的表达。
T14847	B I09	Others; IRE1	Cell Cycle/Checkpoint; Others
	B I09是一种 IRE-1 RNase 抑制剂，IC50为1230 nM，对人 WaC3细胞中 XBP1 mRNA 的剪接和 LPS 刺激的 B 细胞中 xbp -1的表达有抑制作用。B I09可用于 CLL 细胞模拟XBP-1缺陷的研究。
T10866	Cot inhibitor-2	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-2 是一种 cot (Tpl2/MAP3K8) 抑制剂(IC50 : 1.6 nM)，具有有效性，选择性和口服活性。Cot inhibitor-2 对LPS 刺激的人全血中 TNF-α 的产生具有抑制作用，IC50 为 0.3 μM。
T2384	Pomalidomide CC-4047,泊马度胺	Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Pomalidomide (CC-4047) 是一种抗血管生成剂和免疫调节剂，以分子胶的方式作用。它与 E3 连接酶 cereblon 相互作用，诱导必需的 Ikaros 转录因子的降解。
T60442	NLRP3/AIM2-IN-3	NOD; AIM2	Immunology/Inflammation; NF-κB
	NLRP3/AIM2-IN-3 是一种独特的分子，能以物种特异性的方式抑制 NLRP3 和 AIM2 炎性体的激活。它对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3是一种 NLRP3 和 AIM2 炎症体依赖性细胞裂解的强效抑制剂，对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3 可抑制 LPS/nigericin 刺激的 THP-1 巨噬细胞的细胞裂解，其 IC50 值为 0.077 ± 0.008 μM。NLRP3/AIM2-IN-3 干扰了 NLRP3 或 AIM2 与桥接蛋白 ASC 的相互作用，抑制了 ASC 的寡聚。
TP1978	11R-VIVIT NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse
T26776	Berteroin OR-009512,KB-47947,LP-088984,KB47947,LP088984
	Berteroin is an erucin homolog and potential antioxidant. It is present in cruciferous vegetables, including rucola salad leaves, Chinese cabbage and mustard oil. It decreases the release of pro-inflammatory cytokines in LPS-stimulated macrophages. It als
T10298	AMG-548 hydrochloride (864249-60-5 free base) AMG-548 hydrochloride	p38 MAPK	MAPK
	AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).
T63364	Nrf2 activator-5
	Nrf2 activator-5 是 Nrf2 的有效激活剂，能够减轻 BV-2 小胶质细胞中 H2O2诱导的氧化应激和 LPS 刺激的炎症，表现出抗氧化和抗炎活作用。
T36260	NR 7h
	Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo.
T61042	TBT1
	TBT1 是Acinetobacter 菌株中的 MsbA ATPase 刺激剂和LPS 转运抑制剂。TBT1 以13 μM 的 EC50 值刺激 ATPase 活性。TBT1 是MsbA 转运蛋白的一代抑制剂。
T36401	DCVC
	DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p...
T10298L	AMG-548	p38 MAPK	MAPK
	AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM
T73667	Motapizone
	Motapizone (NAT 05-239) 是一种选择性 PDE3抑制剂。Motapizone 适度抑制脂多糖 (LPS) 诱导的肺泡巨噬细胞中细胞因子的释放。Motapizone 还通过增加细胞内 cAMP 来抑制人血小板聚集。
T82373	FPR2 agonist 3
	FPR2 agonist 3 能够抑制 LPS 刺激下的培养物中乳酸脱氢酶的释放，并减少促炎性因子IL-1β和IL-6的表达水平。此外，FPR2 agonist 3 还可以通过作用于 STAT3/SOCS3 信号通路来降低 STAT3 的磷酸化水平。
T10298L2	AMG-548 dihydrochloride (864249-60-5 free base) AMG-548 dihydrochloride	p38 MAPK	MAPK
	AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulate
T37726	MMP-9 Inhibitor I
	MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
T37313	ITH15004
	ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA). 1.Calzaferri, F., Narros-Fernández, P., de Pa...
T71510	MF-592
	MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further de...
T36452	1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
	1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differe...
T36988	N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone
	N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone is a long-chain N-acyl-homoserine lactone (AHL) produced by some Gram-negative bacteria and is involved in quorum sensing. Quorum sensing enables bacteria to change gene expression based on cues from nearby bacteria and from eukaryotic hosts about nutrients, environmental conditions, or threats. Due to the benefit of quorum sensing for bacterial survival, quorum sensing molecules are potential targets for controlling bacterial infections. In...
T63371	AMG-548 hydrochloride
	AMG-548 hydrochloride 是选择性的、口服具有活力的 p38α 抑制剂，Ki 值为 0.5 nM，对p38β略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有高于1000 倍的选择性。AMG 548 hydrochloride 同时能够有效抑制全血 LPS 刺激的TNFα，IC50值为 3 nM。AMG-548 hydrochloride 能够直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε ，进而对 Wnt 信号传导具有抑制作用。
T63762	AMG-548 dihydrochloride
	AMG-548 dihydrochloride 是选择性的、口服具有活力的 p38α 抑制剂，Ki 值为 0.5 nM，对 p38β略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有 >1000 倍的选择性。AMG-548 dihydrochloride 对全血 LPS 刺激的 TNFα 表现出抑制作用，IC50 值为 3 nM。AMG-548 dihydrochloride 能够直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε ，并抑制 Wnt 信号传导。
T37270	9(E),11(E)-12-nitro Conjugated Linoleic Acid
	9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma. 1.Woodcock, S.R., Salvato...
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T35468	(±)19(20)-EDP Ethanolamide
	(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-...
T36017	PF-05381941
	PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1]. PF-05381941 inhibits LPS-stimulated release of TNF-αfrom human peripheralmononuclear (PMN) cells with an IC50 of 8 nM[1]. [1]. Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505.
T83829	2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate sodium ε-dATP
	ε-dATP是一种具有荧光性的嘌呤核苷酸2’-脱氧腺苷-5’-O-三磷酸（dATP）衍生物。它能在50至150µM的浓度范围内诱导初级小鼠脾脏T细胞和B细胞在脂多糖(LPS)或刀豆蛋白A刺激下发生姊妹染色单体交换。ε-dATP已被用于研究乙烯氯诱导的突变过程中模糊碱基配对的情况。相关的ATP衍生物ε-ATP，在300 nm激发下显示415 nm的发射峰值。
T36517	Resveratrol-3-O-sulfate sodium
	Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at conc...
T69831	RPR-200765A Mesylayte
	RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). At oral doses between 10 and 30 mg/kg/day it reduces the incidence and progression in the rat streptococcal cell wall (SCW) arthritis model when administered in either prophylactic or therapeutic dosing regimens. The compound, which is a mesylate salt and exists as a stable m...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T83735	Pap12-6 TFA
	Pap12-6是一种从蝶类P. xuthus幼虫中发现的papiliocin十二个N-端氨基酸衍生的抗菌肽。它对包括E. coli、P. aeruginosa和S. syphimurium在内的八种革兰氏阴性细菌（MIC50s = 4-8 µM）以及革兰氏阳性细菌S. aureus、耐甲氧西林的S. aureus 3126（MRSA-3126）、B. subtilis和S. epidermidis（MIC50s = 4-8 µM）具有活性，但在25 µM浓度下不影响人类红细胞、小鼠RAW 264.7巨噬细胞、人类HaCaT角质形成细胞或人类HEK293肾细胞的活性。Pap12-6在4和8 µM浓度下可引起E. coli的膜去极化。Pap12-6（10 µM）预处理可降低LPS刺激的RAW 264.7巨噬细胞中一氧化氮（NO2-）、Tnf-α和Il-6的分泌水平。在体内，Pap12-6（10 mg/kg）可以提高感染E. coli的小鼠的存活率，并且在剂量为1 mg/kg时减少感染E. coli小鼠的肺、肝和肾中菌落形成单位（CFUs）的数量。Pap12-6（1 mg/kg）在E. co...
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...

化合物

Anti-inflammatory agent 42

Cat.No: T75174

Target: IL Receptor, TNF

Cat.No: T14847

Target: Others, IRE1

Cot inhibitor-2

Cat.No: T10866

Target: TNF, MAPK

Cat.No: T2384

Synonym: CC-4047,泊马度胺

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

NLRP3/AIM2-IN-3

Cat.No: T60442

Target: NOD, AIM2

Cat.No: TP1978

Synonym: NFAT inhibitor, Cell Permeable

Cat.No: T26776

Synonym: OR-009512,KB-47947,LP-088984,KB47947,LP088984

AMG-548 hydrochloride (864249-60-5 free base)

Cat.No: T10298

Synonym: AMG-548 hydrochloride

Target: p38 MAPK

Nrf2 activator-5

Cat.No: T63364

Cat.No: T36260

Cat.No: T61042

Cat.No: T36401

Cat.No: T10298L

Target: p38 MAPK

Cat.No: T73667

Cat.No: T82373

AMG-548 dihydrochloride (864249-60-5 free base)

Cat.No: T10298L2

Synonym: AMG-548 dihydrochloride

Target: p38 MAPK

MMP-9 Inhibitor I

Cat.No: T37726

Cat.No: T37313

Cat.No: T71510

1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)

Cat.No: T36452

N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone

Cat.No: T36988

AMG-548 hydrochloride

Cat.No: T63371

AMG-548 dihydrochloride

Cat.No: T63762

9(E),11(E)-12-nitro Conjugated Linoleic Acid

Cat.No: T37270

Cat.No: T36408

Synonym: Rhein-13C4

(±)19(20)-EDP Ethanolamide

Cat.No: T35468

Cat.No: T36017

2'-Deoxy-1,N6-ethenoadenosine-5'-O-triphosphate sodium

Cat.No: T83829

Synonym: ε-dATP

Resveratrol-3-O-sulfate sodium

Cat.No: T36517

RPR-200765A Mesylayte

Cat.No: T69831

Cat.No: T36629

Cat.No: T83735

Cat.No: T36486

Cat. No.	Product Name	Target	Signaling Pathways
T4592	TOMATIDINE HYDROCHLORIDE Tomatidine,Tomatidine HCl,盐酸番茄碱	Others; NF-κB; JNK; Autophagy	Autophagy; MAPK; NF-κB; Others
	Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱，可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用，可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。
TCS2170	2,5-Dihydroxyacetophenone Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 '，5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP	ERK; NF-κB; Tyrosinase	MAPK; NF-κB; Proteases/Proteasome
	2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物，通过阻断 ERK1/2和 NF-κB 信号通路，抑制活化巨噬细胞中炎症介质的产生。
T6S1543	Dehydrodiisoeugenol 去氢二异丁香酚,脱氢二异丁香酚	Others; NF-κB; COX; Antibacterial	Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Others
	Dehydrodiisoeugenol 是从Myristica fragrans Houtt 中分离得到的天然产物，具有抗炎和抗菌作用。它抑制 LPS 刺激的小鼠巨噬细胞中NF-κB 活化和环氧合酶 (COX)-2 基因的表达。
T3039	Hederagenin Hederagenic acid,常春藤苷元,Astrantiagenin E,Caulosapogenin,常春藤皂苷元,Hederagenol	Others	Others
	Hederagenin (Hederagenol) 是一种三萜皂苷，可以抑制细胞中由于LPS 刺激引起的 iNOS、COX-2和 NF-κB 的表达。
T5773	Moslosooflavone 5-羟基-7,8-二甲氧基黄酮,5-hydroxy-7,8-dimethoxyflavone	NF-κB; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) 是一种从雪莲中分离出来的类黄酮，具有抗缺氧和抗炎作用。
T6S0117	Avicularin Fenicularin,扁蓄苷	ERK	MAPK
	Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
T4479	Isomaculosidine	Others	Others
	Isomaculosidine can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
T38820	Methylsyringin
	Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.
TN4827	Preskimmianine	Others	Others
	Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
TN4938	Samidin	p38 MAPK; TNF; NF-κB; COX; DNA/RNA Synthesis; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN3241	7-O-Acetylbonducellpin C	Others	Others
	7-O-Acetylbonducellpin C may exhibit significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).
T40866	8-Methylsulfinyloctyl isothiocyanate
	8-Methylsulfinyloctyl isothiocyanate is a compound with antimicrobial activity and notable inhibitory effects on plant growth. It also exhibits COX-2-mediated inflammatory response impairment in LPS-stimulated raw macrophages.
TN2178	Sanggenone H	IL Receptor; TNF; NF-κB	Apoptosis; Immunology/Inflammation; NF-κB
	Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.
TN5033	Skullcapflavone I	IL Receptor; Caspase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se
TN1235	3,4,5-Tricaffeoylquinic acid	TNF; Akt; HIV Protease	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.
TN4648	Nepetoidin B	IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; Antibacterial; JNK; Antifection; Antifungal	Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB
	Nepetoidin B 具有抗真菌、抗细菌和抗炎作用，它可以抑制 LPS 刺激的 NO 生成，可能是通过调节 RAW 264.7 细胞中由 MKP-5/NF-ÎºB 通路介导的 iNOS 。
TN6539	Pd-C-II
	Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release from purified mast cells induced by
TN4465	Luvangetin	COX; Prostaglandin Receptor; Antifection	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced
T38929	2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside
	2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside that is commonly found in the bulbs of Lilium brownie var. viridulum. This compound has been observed to exhibit a weak inhibition of NO production in LPS-stimulated RAW 264.7 cells.
TN5011	Shizukaol B	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul
T26545	Acanthoic acid NP1302,NP 1302: NP-1302
	Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits infla
TQ0073	Andropanolide	HIV Protease; NO Synthase; Parasite	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Andropanolide 是一种来自穿心莲的二帖类化合物，具有抗HIV、抗疟和抗癌活性，对 Lipopolysaccharides (LPS) 刺激的 RAW264.7 巨噬细胞中一氧化氮 (NO) 的过量产生有抑制作用。
TN1109	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid,3-O-乙酰基-16Α-羟基松苓新酸	NOS; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) 是三萜类化合物。它能够作用于 LPS 刺激的 Raw264.7 细胞，减少NO 产生和 iNOS 表达，具有消炎作用。
TN4879	Questinol	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 and inhibit NO an
T27282	Erucin AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056
	Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-induced neurodegenration, and inhib
TN4146	Glutinol acetate	TNF	Apoptosis
	Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line.
TN4637	Neogrifolin	PARP; GSK-3; Akt; Caspase	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with the IC50value of 23.3 microM. Neogrifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, the MIC values of 20 and 0.5 microg/mL, respe...
T72208	1-Dehydro-[10]-gingerdione
	1-Dehydro-[10]-gingerdione 通过靶向IKKβ的激活环直接抑制 IKKβ 活性，从而破坏用激动剂刺激的巨噬细胞中 IKKβ 催化的 IκBα 磷酸化。1-Dehydro-[10]-gingerdione 抑制 LPS 诱导的NF-κB 转录活性。1-Dehydro-[10]-gingerdione 具有用于NF-κB 相关炎症和自身免疫性疾病研究的潜力。
TN4190	Hedycoronen A	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 uM, they also show moderate inhibitory activity on
TN4635	Neoechinulin A	NADPH-oxidase; Beta Amyloid; ASK; IκB/IKK; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu
T5157	9,13-Epidioxy-8(14)-abieten-18-oic acid	Others	Others
	9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory...
TN2169	Saikogenin D 柴胡皂甙元 D,皂苷元 D	IL Receptor; Calcium Channel; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores. Saikogenin D has immuno
TN3539	Broussonin A	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju
T37911	cis-Resveratrol 顺式白藜芦醇,(Z)-Resveratrol
	Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase ...

天然产物

TOMATIDINE HYDROCHLORIDE

Cat.No: T4592

Synonym: Tomatidine,Tomatidine HCl,盐酸番茄碱

Target: Others, NF-κB, JNK, Autophagy

2,5-Dihydroxyacetophenone

Cat.No: TCS2170

Synonym: Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 '，5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP

Target: ERK, NF-κB, Tyrosinase

Dehydrodiisoeugenol

Cat.No: T6S1543

Synonym: 去氢二异丁香酚,脱氢二异丁香酚

Target: Others, NF-κB, COX, Antibacterial

Cat.No: T3039

Synonym: Hederagenic acid,常春藤苷元,Astrantiagenin E,Caulosapogenin,常春藤皂苷元,Hederagenol

Target: Others

Moslosooflavone

Cat.No: T5773

Synonym: 5-羟基-7,8-二甲氧基黄酮,5-hydroxy-7,8-dimethoxyflavone

Target: NF-κB, Reactive Oxygen Species

Cat.No: T6S0117

Synonym: Fenicularin,扁蓄苷

Target: ERK

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

Isomaculosidine

Cat.No: T4479

Target: Others

Cat.No: T38820

Cat.No: TN4827

Target: Others

Cat.No: TN4938

Target: p38 MAPK, TNF, NF-κB, COX, DNA/RNA Synthesis, JNK

7-O-Acetylbonducellpin C

Cat.No: TN3241

Target: Others

8-Methylsulfinyloctyl isothiocyanate

Cat.No: T40866

Cat.No: TN2178

Target: IL Receptor, TNF, NF-κB

Skullcapflavone I

Cat.No: TN5033

Target: IL Receptor, Caspase, Prostaglandin Receptor

3,4,5-Tricaffeoylquinic acid

Cat.No: TN1235

Target: TNF, Akt, HIV Protease

Cat.No: TN4648

Target: IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, Antibacterial, JNK, Antifection, Antifungal

Cat.No: TN6539

Cat.No: TN4465

Target: COX, Prostaglandin Receptor, Antifection

2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside

Cat.No: T38929

Cat.No: TN5011

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Cat.No: T26545

Synonym: NP1302,NP 1302: NP-1302

Cat.No: TQ0073

Target: HIV Protease, NO Synthase, Parasite

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid

Cat.No: TN1109

Synonym: 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid,3-O-乙酰基-16Α-羟基松苓新酸

Target: NOS, NO Synthase, Prostaglandin Receptor

Cat.No: TN4879

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

Cat.No: T27282

Synonym: AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056

Glutinol acetate

Cat.No: TN4146

Target: TNF

Cat.No: TN4637

Target: PARP, GSK-3, Akt, Caspase

1-Dehydro-[10]-gingerdione

Cat.No: T72208

Cat.No: TN4190

Target: IL Receptor, TNF

Cat.No: TN4635

Target: NADPH-oxidase, Beta Amyloid, ASK, IκB/IKK, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor

9,13-Epidioxy-8(14)-abieten-18-oic acid

Cat.No: T5157

Target: Others

Cat.No: TN2169

Synonym: 柴胡皂甙元 D,皂苷元 D

Target: IL Receptor, Calcium Channel, Prostaglandin Receptor

Cat.No: TN3539

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

Cat.No: TN4411

Target: CDK, P-gp, JNK

cis-Resveratrol

Cat.No: T37911

Synonym: 顺式白藜芦醇,(Z)-Resveratrol

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