| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T5674 | H-151 | STING | Immunology/Inflammation |
| H-151 是选择性和共价的STING 拮抗剂，可减少 TBK1 磷酸化并抑制 STING 棕榈酰化，在体内外均具有显著的抑制活性，可用于自身炎症性疾病的研究。 | |||
| T38160 | STING Agonist 1a | ||
| STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir... | |||
| T37666 |
Trihydroxycholestanoic Acid
Trihydroxycoprostanic Acid |
||
| Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid .1 Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.2,3 |1. Keane, M.H., Overmars, H., Wikander, T.M., et al. Bile acid treatment alters hepatic disease and bile acid transport in peroxisome-deficient PEX2 Zellweger mice. Hepatology 45(4), 982-997 ... | |||
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