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Targets Recommended: STING

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Cat. No. Product Name Target Signaling Pathways
T5674 H-151

STING Immunology/Inflammation
H-151 是选择性和共价的STING 拮抗剂,可减少 TBK1 磷酸化并抑制 STING 棕榈酰化,在体内外均具有显著的抑制活性,可用于自身炎症性疾病的研究。
T38160 STING Agonist 1a

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir...
T37666 Trihydroxycholestanoic Acid

Trihydroxycoprostanic Acid

Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid .1 Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.2,3 |1. Keane, M.H., Overmars, H., Wikander, T.M., et al. Bile acid treatment alters hepatic disease and bile acid transport in peroxisome-deficient PEX2 Zellweger mice. Hepatology 45(4), 982-997 ...

化合物

H-151
T5674
synonym:
Target: STING
STING Agonist 1a
T38160
synonym:
Target:
Trihydroxycholestanoic Acid
T37666
synonym: Trihydroxycoprostanic Acid
Target:
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