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TargetMol产品目录中 "

GPR40 Agonist 2

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  • 抑制剂&激动剂
    13
    TargetMol | Inhibitors_Agonists
  • GPR40 Agonist 2
    T105071147729-48-3
    GPR40 Agonist 2 is a GPR40 agonist. It can be used in the research of diabetes.
    • ¥ 13900
    8-10周
    规格
    数量
  • LY2881835
    LY 2881835, LY-2881835
    T279371292290-38-0In house
    LY2881835 是一种特异性 G 蛋白偶联受体 40 (GPR40) 激动剂,具有潜在的降血糖活性,可增强的葡萄糖刺激正常瘦小鼠的胰岛素分泌。LY2881835 可用于研究 2 型糖尿病。
    • ¥ 1980
    现货
    规格
    数量
  • TUG-499
    T601841206629-08-4
    TUG-499 是一种选择性游离脂肪酸受体 1 (FFAR1 或 GPR40)激动剂(EC50 : 7.39)。TUG-499对 FFAR1 或 GPR40的亲和力超过相关受体 FFA2、FFA3 和核受体 PPARγ,以及其他不同的受体、离子通道和转运蛋白。TUG-499 可用于研究 2 型糖尿病。
    • ¥ 248
    现货
    规格
    数量
    TargetMol | Inhibitor Sale
  • CPL207280
    T860872361497-72-3
    CPL207280是一种具有口服活性的GPR40 FFA1激动剂,具有抗糖尿病作用。CPL207280可有效增强葡萄糖刺激胰岛素分泌,改善MIN6胰腺β细胞、健康Wistar Han大鼠和糖尿病大鼠模型的葡萄糖耐受性。CPL207280可用于2型糖尿病的研究。
    • 待询
    10-14周
    规格
    数量
  • ZLY032
    T358162314465-67-1
    ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1 GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob obmouse model of metabolic disease.2It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose. 1.Li, Z., Chen, Y., Zhou, Z., et al.Discovery of first-in-class thiazole-based dual FFA1 PPARδ agonists as potential anti-diabetic agentsEur. J. Med. Chem.164352-365(2019) 2.Li, Z., Zhou, Z., Hu, L., et al.ZLY032, the first-in-class dual FFA1 PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosisPharmacol Res.159105035(2020)
    • 待估
    35日内发货
    规格
    数量
  • GPR40 agonist 1
    T114591853982-41-8
    GPR40 agonist 1 is an effective new GPR40 agonist (EC50s: 17 nM and 2 nM for rGPR40 and hGPR40).
    • ¥ 11700
    6-8周
    规格
    数量
  • TUG-770
    TUG770, TUG 770
    TQ02411402601-82-4
    TUG-770 是一种具有口服活性、选择性和高效性的 GPR40 FFA1 激动剂,具有潜在的抗炎活性。TUG-770 可用于研究 2 型糖尿病、痴呆和阿尔茨海默症。
    • ¥ 723
    5日内发货
    规格
    数量
  • ZQ 16
    T36634376616-73-8
    Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro. Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID:27326330 |Zhang et al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337 PMID:26962172
    • ¥ 591
    5日内发货
    规格
    数量
  • MK-8666
    T704681544739-76-5
    MK-8666 is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.
    • ¥ 27790
    8-10周
    规格
    数量
  • BI-2081
    T734341458656-71-7
    BI-2081是一种GPR40 (FFAR1)部分激动剂,具有EC50值为4 nM。该化合物能诱导葡萄糖依赖性胰岛素释放,并降低血浆中葡萄糖含量,适用于研究代谢疾病,尤其是2型糖尿病。
    • ¥ 13900
    8-10周
    规格
    数量
  • MK-8666 Tris
    T699532056254-98-7
    MK-8666 Tris is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 Tris has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.
    • ¥ 13900
    8-10周
    规格
    数量
  • GPR40 agonist 5
    T625422443384-60-7
    GPR40 agonist 5 是一种口服具有活力的 GPR40 (G 蛋白偶联受体 40) 激动剂 (EC50: 47 nM)。GPR40 agonist 5 能够减少血糖水平,改善糖耐量。GPR40 agonist 5 对 2 型糖尿病小鼠的高血糖状态表现出充足的控制作用。
    • ¥ 10600
    6-8周
    规格
    数量
  • LY2922470
    T158101423018-12-5
    LY2922470 是选择性口服有效的GPR40激动剂,作用于 人 GPR40、小鼠 GPR40、大鼠 GPR40 的EC50值分别为 7 nM、1 nM、3 nM。它可降低血糖水平,同时显著增加胰岛素和 GLP-1,有潜力用于 2 型糖尿病的研究。
    • ¥ 953
    现货
    规格
    数量
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