| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T14998 |
Copanlisib dihydrochloride
库潘尼西盐酸; BAY 80-6946 dihydrochloride |
Apoptosis; PI3K; mTOR | Apoptosis; PI3K/Akt/mTOR signaling |
| Copanlisib dihydrochloride 是一种选择性和 ATP 竞争性的泛 I 类PI3K抑制剂。它具有优越的抗肿瘤活性，对除 mTOR 以外的其他脂质和蛋白激酶的选择性也超过 2,000 倍。 | |||
| T70758 | Copanlisib HCl hydrate | ||
| Copanlisib Dihydrochloride is a novel phosphoinositide 3-kinase (pi3k) inhibitor, inhibiting the activation of the pi3k signaling pathway, resulting in inhibition of tumor cell growth and survival in susceptible tumor cell populations | |||
| T70756 | KT172 | ||
| KT172 is a non-selective inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGLα or DAGLβ. KT172 also inhibits α/β-hydrolase 6 (ABHD6) and weakly inhibits monoacylglycerol lipase (MAGL). It restores nicotine-stimulated GABA release in isolated ventral tegmental area (VTA) dopamine neurons from rats chronically exposed to nicotine. KT172 decreases production of 2-arachi... | |||
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