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TL1A/TNFSF15 Protein, Human, Recombinant (His)

产品编号 TMPY-05802

别名: TL1A, VEGI, VEGI192A, tumor necrosis factor (ligand) superfamily, member 15, TL1

TL1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.8 kDa and the accession number is A0A0U5JA19.

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TL1A/TNFSF15 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,430		5日内发货
1 mg	￥ 22,400		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	TL1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.8 kDa and the accession number is A0A0U5JA19.

种属	Human
表达系统	HEK293 Cells
标签	N-His
蛋白编号	A0A0U5JA19
别名	TL1A, VEGI, VEGI192A, tumor necrosis factor (ligand) superfamily, member 15, TL1
蛋白构建	Human TNFSF15 (NP_005109.2) (Leu72-Leu251)
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	22.8 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

参考文献

1. Jin T, et al. (2007) X-ray crystal structure of TNF ligand family member TL1A at 2.1A. Biochem Biophys Res Commun. 364(1):1-6. 2. Cassatella MA, et al. (2007) Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. J Immunol. 178(11):7325-33. 3. Prehn JL, et al. (2007) The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol. 178(7):4033-8.

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Keywords

TL1A/TNFSF15 Protein, Human, Recombinant (His) TL1A VEGI TL-1 VEGI192A TL 1 tumor necrosis factor (ligand) superfamily, member 15 TL1 recombinant recombinant-proteins proteins protein

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