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Glypican 3/GPC3 Protein, Mouse, Recombinant (His)

Glypican 3/GPC3 Protein, Mouse, Recombinant (His)

产品编号 TMPY-00502
别名: OCI-5, glypican 3

Glypican 3/GPC3 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 62 kDa and the accession number is Q3TWB2.

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Glypican 3/GPC3 Protein, Mouse, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 2,730 现货
200 μg ¥ 4,840 5日内发货
500 μg ¥ 10,250 5日内发货
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产品目录号及名称: Glypican 3/GPC3 Protein, Mouse, Recombinant (His) (TMPY-00502)
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参考文献
生物活性 Measured by its ability to bind biotinylated human FGF basic in a functional ELISA.
产品描述 Glypican 3/GPC3 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 62 kDa and the accession number is Q3TWB2.
种属 Mouse
表达系统 Baculovirus Insect Cells
标签 C-His
蛋白编号 Q3TWB2
别名 OCI-5, glypican 3
蛋白构建 Mouse GPC3 (NP_057906.2) (Met1-Pro558)
蛋白纯度 > 95 % as determined by SDS-PAGE

TargetMol

分子量 62 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue-dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceed both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

Glypican 3/GPC3 Protein, Mouse, Recombinant (His) OCI 5 OCI-5 glypican 3 OCI5 recombinant recombinant-proteins proteins protein

 

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