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Glypican 3/GPC3 Protein, Human, Recombinant (S495A, hFc)

产品编号 TMPY-05805

Glypican 3/GPC3 Protein, Human, Recombinant (S495A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 86.46 kDa and the accession number is I6QTG3.

Glypican 3/GPC3 Protein, Human, Recombinant (S495A, hFc)

产品编号 TMPY-05805

Glypican 3/GPC3 Protein, Human, Recombinant (S495A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 86.46 kDa and the accession number is I6QTG3.

规格	价格	库存	数量
50 μg	¥ 2,270	5日内发货
500 μg	¥ 14,800	5日内发货

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产品信息

生物活性	Measured by its binding ability in a functional ELISA. Immobilized FGF2 Protein, Human at 2 μg/mL (100 μL/well) can bind Glypican 3 Protein, Human, Recombinant (495S/A, hFc Tag), the EC50 of Glypican 3 is 0.75-1.1 μg/mL.
产品描述	Glypican 3/GPC3 Protein, Human, Recombinant (S495A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 86.46 kDa and the accession number is I6QTG3.
种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	I6QTG3
别名	SGBS1,SGBS,SGB,SDYS,OCI-5,MXR7,GTR2-2,glypican 3,DGSX
蛋白构建	A DNA sequence encoding the human GPC3 (NP_004475.1, with mutation Ser 495 Ala) (Met1-Ser550) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Gln 25
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	86.46 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue-dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceed both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy