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Anti-EFNA1 Monoclonal Antibody

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产品编号 TMAZ-0208

别名 Tumor necrosis factor alpha-induced protein 4, Immediate early response protein B61, Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1

Anti-EFNA1 Monoclonal Antibody is a humanized rabbit antibody targeting EFNA1. Anti-EFNA1 Monoclonal Antibody can be used in ELISA, FCM. 可用于 ELISA,FCM。

Anti-EFNA1 Monoclonal Antibody

Anti-EFNA1 Monoclonal Antibody

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产品编号 TMAZ-0208 别名 Tumor necrosis factor alpha-induced protein 4, Immediate early response protein B61, Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1

Anti-EFNA1 Monoclonal Antibody is a humanized rabbit antibody targeting EFNA1. Anti-EFNA1 Monoclonal Antibody can be used in ELISA, FCM. 可用于 ELISA,FCM。

规格价格库存数量
25 μg
¥ 1,250
7日内发货
50 μg
¥ 1,500
7日内发货
100 μg
¥ 2,099
7日内发货
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产品介绍

生物活性
产品描述
Anti-EFNA1 Monoclonal Antibody is a humanized rabbit antibody targeting EFNA1. Anti-EFNA1 Monoclonal Antibody can be used in ELISA,FCM.
别名Tumor necrosis factor alpha-induced protein 4, Immediate early response protein B61, Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of EFNA1 overexpressed 436F cells with TMAZ-0208, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用ELISAFCM
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of EFNA1 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin
可提供抗体种类
2
抗原信息
免疫原
EFNA1
抗原种属
Human
基因ID
1942
Uniprot ID
P20827
研究领域
Cytokines
化学信息
分子量150 kDa
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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