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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-TrkC Antibody (7A349)

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货号 TMAB-13822

Anti-TrkC Antibody (7A349) 是一种 Mouse 抗体，靶向 TrkC。Anti-TrkC Antibody (7A349) 可用于 WB。

Anti-TrkC Antibody (7A349)

Anti-TrkC Antibody (7A349)

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Rating icon 还可以
货号 TMAB-13822

Anti-TrkC Antibody (7A349) 是一种 Mouse 抗体，靶向 TrkC。Anti-TrkC Antibody (7A349) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
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产品介绍

生物活性
产品描述
Anti-TrkC Antibody (7A349) is a Mouse antibody targeting TrkC. Anti-TrkC Antibody (7A349) can be used in WB.
Ig Type
IgG1, k
克隆号
7A349
反应种属
Human,Mouse,Rat
应用WB
推荐剂量
WB: 1:500-1000
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Membrane; Single-pass type I membrane protein.
组织特异性Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor, gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.
抗原信息
免疫原
Recombinant Protein: human Ntrk3
抗原种属
Human
基因名称
NTRK3
基因ID
4916
蛋白名称
NT-3 growth factor receptor
Uniprot ID
Q16288
功能
Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
化学信息
分子量Theoretical: 91 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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