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Anti-TDP-43 Antibody (8P357)

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货号 TMAB-13441

Anti-TDP-43 Antibody (8P357) 是一种 Mouse 抗体，靶向 TDP-43。Anti-TDP-43 Antibody (8P357) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-TDP-43 Antibody (8P357)

Anti-TDP-43 Antibody (8P357)

一键复制产品信息
Rating icon 还可以
货号 TMAB-13441

Anti-TDP-43 Antibody (8P357) 是一种 Mouse 抗体，靶向 TDP-43。Anti-TDP-43 Antibody (8P357) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-TDP-43 Antibody (8P357) is a Mouse antibody targeting TDP-43. Anti-TDP-43 Antibody (8P357) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG1, Kappa
克隆号
8P357
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:1000-5000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Nucleus. In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.
组织特异性Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
构建方式Recombinant Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
抗原信息
基因名称
TARDBP
基因ID
23435
蛋白名称
TAR DNA-binding protein 43
功能
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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