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Anti-PSMB8 Antibody (7P785)

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货号 TMAB-11869

Anti-PSMB8 Antibody (7P785) 是一种 Mouse 抗体，靶向 PSMB8。Anti-PSMB8 Antibody (7P785) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-PSMB8 Antibody (7P785)

Anti-PSMB8 Antibody (7P785)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11869

Anti-PSMB8 Antibody (7P785) 是一种 Mouse 抗体，靶向 PSMB8。Anti-PSMB8 Antibody (7P785) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-PSMB8 Antibody (7P785) is a Mouse antibody targeting PSMB8. Anti-PSMB8 Antibody (7P785) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG1, Kappa
克隆号
7P785
反应种属
Human,Rat
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-1000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasm. Nucleus.
组织特异性Highly expressed in immature dendritic cells (at protein level).
构建方式Recombinant Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008].
抗原信息
基因名称
PSMB8
基因ID
5696
蛋白名称
Proteasome subunit beta type-8
功能
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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