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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody

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货号 TMAB-10547

Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CRMP2 (Thr514)。Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody 可用于 WB,IHC-P,IF。

Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody

Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10547

Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CRMP2 (Thr514)。Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody 可用于 WB,IHC-P,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CRMP2 (Thr514). Anti-Phospho-CRMP2 (Thr514) Polyclonal Antibody can be used in WB,IHC-P,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Chicken,Dog,Cow,Horse,Rabbit)
应用WBIHC-PIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
组织特异性Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human CRMP-2 around the phosphorylation site of Thr514
抗原种属
Human
基因名称
DPYSL2
基因ID
1808
蛋白名称
Dihydropyrimidinase-related protein 2
Uniprot ID
Q16555
功能
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
化学信息
分子量Theoretical: 62 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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