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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Phospho-Bid (Ser61) Polyclonal Antibody

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货号 TMAB-10402

Anti-Phospho-Bid (Ser61) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Bid (Ser61)。Anti-Phospho-Bid (Ser61) Polyclonal Antibody 可用于 FCM。

Anti-Phospho-Bid (Ser61) Polyclonal Antibody

Anti-Phospho-Bid (Ser61) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-10402

Anti-Phospho-Bid (Ser61) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Bid (Ser61)。Anti-Phospho-Bid (Ser61) Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Bid (Ser61) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Bid (Ser61). Anti-Phospho-Bid (Ser61) Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse)
应用FCM
推荐剂量
FCM: 0.2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm (By similarity). Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. BH3-interacting domain death agonist p15: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membran. Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.
组织特异性Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: mouse Bid around the phosphorylation site of Ser61
抗原种属
Mouse
基因名称
BID
基因ID
12122
蛋白名称
BH3-interacting domain death agonist
Uniprot ID
P70444
功能
The major proteolytic product p15 BID allows the release of cytochrome c. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
化学信息
分子量Theoretical: 21 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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