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顶部产品介绍抗原信息储存和溶解信息计算器

Anti-PABPN1 Antibody (5O419)

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货号 TMAB-09912

Anti-PABPN1 Antibody (5O419) 是一种 Mouse 抗体，靶向 PABPN1。Anti-PABPN1 Antibody (5O419) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-PABPN1 Antibody (5O419)

Anti-PABPN1 Antibody (5O419)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09912

Anti-PABPN1 Antibody (5O419) 是一种 Mouse 抗体，靶向 PABPN1。Anti-PABPN1 Antibody (5O419) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-PABPN1 Antibody (5O419) is a Mouse antibody targeting PABPN1. Anti-PABPN1 Antibody (5O419) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG1, Kappa
克隆号
5O419
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-1000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasmic and Nuclear.
组织特异性Ubiquitous.
构建方式Recombinant Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]
抗原信息
基因名称
PABPN1
基因ID
8106
蛋白名称
Polyadenylate-binding protein 2
功能
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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