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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MLKL Antibody (4Y79)

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货号 TMAB-08855

Anti-MLKL Antibody (4Y79) 是一种 Rabbit 抗体，靶向 MLKL。Anti-MLKL Antibody (4Y79) 可用于 WB。

Anti-MLKL Antibody (4Y79)

Anti-MLKL Antibody (4Y79)

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Rating icon 还可以
货号 TMAB-08855

Anti-MLKL Antibody (4Y79) 是一种 Rabbit 抗体，靶向 MLKL。Anti-MLKL Antibody (4Y79) 可用于 WB。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-MLKL Antibody (4Y79) is a Rabbit antibody targeting MLKL. Anti-MLKL Antibody (4Y79) can be used in WB.
Ig Type
IgG
克隆号
4Y79
反应种属
Human
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
抗原信息
免疫原
A synthesized peptide: human MLKL
抗原种属
Human
基因名称
MLKL
基因ID
197259
蛋白名称
Mixed lineage kinase domain-like protein
Uniprot ID
Q8NB16
功能
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
化学信息
分子量Theoretical: 54 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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