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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-KCNQ2 Polyclonal Antibody

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货号 TMAB-07949

Anti-KCNQ2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 KCNQ2。Anti-KCNQ2 Polyclonal Antibody 可用于 FCM。

Anti-KCNQ2 Polyclonal Antibody

Anti-KCNQ2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07949

Anti-KCNQ2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 KCNQ2。Anti-KCNQ2 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-KCNQ2 Polyclonal Antibody is a Rabbit antibody targeting KCNQ2. Anti-KCNQ2 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Cow,Horse,Sheep)
应用FCM
推荐剂量
FCM: 3μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Multi-pass membrane protein.
组织特异性In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Epilepsy affects about 0.5% of the world’s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons. Benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains. Both proteins display a broad distribution within the brain, with expression patterns that largely overlap.
抗原信息
免疫原
KLH conjugated synthetic peptide: human KCNQ2
抗原种属
Human
基因名称
KCNQ2
基因ID
3785
蛋白名称
Potassium voltage-gated channel subfamily KQT member 2
Uniprot ID
O43526
功能
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
化学信息
分子量Theoretical: 96 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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