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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HSF1 Antibody (4S10)

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货号 TMAB-07327

Anti-HSF1 Antibody (4S10) 是一种 Rabbit 抗体，靶向 HSF1。Anti-HSF1 Antibody (4S10) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM。

Anti-HSF1 Antibody (4S10)

Anti-HSF1 Antibody (4S10)

一键复制产品信息
Rating icon 还可以
货号 TMAB-07327

Anti-HSF1 Antibody (4S10) 是一种 Rabbit 抗体，靶向 HSF1。Anti-HSF1 Antibody (4S10) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-HSF1 Antibody (4S10) is a Rabbit antibody targeting HSF1. Anti-HSF1 Antibody (4S10) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,FCM.
Ig Type
IgG
克隆号
4S10
反应种属
Human
应用WBIHC-PIHC-FrICC/IFIFIPFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500; IP: 1:20-50; FCM: 1μg/Test
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Cytoplasmic duringnormal growth. On activation, translocates to nuclear stressgranules. Colocalizes with SUMO1 in nuclear stress granules.
组织特异性Phosphorylated on multiple serine residues, a subset of whichare involved in stress-related regulation of transcriptionactivation. Constitutive phosphorylation represses transcriptionalactivity at normal temperatures. Levels increase on specificresidues heat-shock and enhance HSF1 transactivation activity.Phosphorylation on Ser-307 derepresses activation on heat-stressand in combination with Ser-303 phosphorylation appears to beinvolved in recovery after heat-stress. Phosphorylated on Ser-230by CAMK2, in vitro. Cadmium also enhances phosphorylation at thissite. Phosphorylation on Ser-303 is a prerequisite for HSF1sumoylation. Phosphorylation on Ser-121 inhibits transactivationand promotes HSP90 binding. Phosphorylation on Thr-142 alsomediates transcriptional activity induced by heat.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage.
抗原信息
免疫原
A synthesized peptide: human HSF1
抗原种属
Human
基因名称
HSF1
基因ID
3297
蛋白名称
Heat shock factor protein 1
Uniprot ID
Q00613
功能
DNA-binding protein that specifically binds heat shockpromoter elements (HSE) and activates transcription. In highereukaryotes, HSF is unable to bind to the HSE unless the cells areheat shocked.
化学信息
分子量Theoretical: 57 kDa. Actual: 80 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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