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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HFE Polyclonal Antibody

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货号 TMAB-07006

Anti-HFE Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HFE。Anti-HFE Polyclonal Antibody 可用于 FCM。

Anti-HFE Polyclonal Antibody

Anti-HFE Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07006

Anti-HFE Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HFE。Anti-HFE Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-HFE Polyclonal Antibody is a Rabbit antibody targeting HFE. Anti-HFE Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Cow,Horse,Sheep)
应用FCM
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein.
组织特异性Expressed in all tissues tested except brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
抗原信息
免疫原
KLH conjugated synthetic peptide: Human HFE/Hemochromatosis
抗原种属
Human
基因名称
HFE
基因ID
3077
蛋白名称
Hereditary hemochromatosis protein
Uniprot ID
Q30201
功能
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
化学信息
分子量Theoretical: 38 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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