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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GPR17 Polyclonal Antibody

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货号 TMAB-06699

Anti-GPR17 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GPR17。Anti-GPR17 Polyclonal Antibody 可用于 WB。

Anti-GPR17 Polyclonal Antibody

Anti-GPR17 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-06699

Anti-GPR17 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 GPR17。Anti-GPR17 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-GPR17 Polyclonal Antibody is a Rabbit antibody targeting GPR17. Anti-GPR17 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Rabbit)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane.
组织特异性Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GPR17
抗原种属
Human
基因名称
GPR17
基因ID
2840
蛋白名称
Uracil nucleotide/cysteinyl leukotriene receptor
Uniprot ID
Q13304
功能
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
化学信息
分子量Theoretical: 41 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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