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Anti-Glypican 3/GPC3 Antibody (4J109)
还可以产品编号 TMAY-00147
别名 SGBS1, SGBS, SGB, SDYS, OCI-5, MXR7, GTR2-2, Glypican 3, DGSX
Anti-Glypican 3/GPC3 Antibody (4J109) 是一种 Rabbit 抗体，靶向 Glypican 3/GPC3。Anti-Glypican 3/GPC3 Antibody (4J109) 可用于 FCM。
Anti-Glypican 3/GPC3 Antibody (4J109)
Anti-Glypican 3/GPC3 Antibody (4J109)
还可以产品编号 TMAY-00147 别名 SGBS1, SGBS, SGB, SDYS, OCI-5, MXR7, GTR2-2, Glypican 3, DGSX
Anti-Glypican 3/GPC3 Antibody (4J109) 是一种 Rabbit 抗体，靶向 Glypican 3/GPC3。Anti-Glypican 3/GPC3 Antibody (4J109) 可用于 FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 790 | 5日内发货 | |
| 100 μL | ¥ 2,294 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Glypican 3/GPC3 Antibody (4J109) is a Rabbit antibody targeting Glypican 3/GPC3. Anti-Glypican 3/GPC3 Antibody (4J109) can be used in FCM. |
| 别名 | SGBS1, SGBS, SGB, SDYS, OCI-5, MXR7, GTR2-2, Glypican 3, DGSX |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4J109 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human GPC3 expression on HepG2 cells. Cells were stained with purified anti-Human GPC3, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human Glypican 3 / GPC3 / OCI-5. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue-dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceed both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | A synthetic peptide corresponding to the center region of the Human Glypican 3 / GPC3 / OCI-5 |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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