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Anti-DYNLL1 Antibody (4N356)

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货号 TMAB-05367

Anti-DYNLL1 Antibody (4N356) 是一种 Rabbit 抗体，靶向 DYNLL1。Anti-DYNLL1 Antibody (4N356) 可用于 WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM。

Anti-DYNLL1 Antibody (4N356)

Anti-DYNLL1 Antibody (4N356)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05367

Anti-DYNLL1 Antibody (4N356) 是一种 Rabbit 抗体，靶向 DYNLL1。Anti-DYNLL1 Antibody (4N356) 可用于 WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

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产品描述
Anti-DYNLL1 Antibody (4N356) is a Rabbit antibody targeting DYNLL1. Anti-DYNLL1 Antibody (4N356) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF,FCM.
Ig Type
IgG/Kappa
克隆号
4N356
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrIFICC/IFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
组织特异性Ubiquitous.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
A synthesized peptide: human DYNLL1
基因名称
DYNLL1
基因ID
8655
蛋白名称
Dynein light chain 1, cytoplasmic
功能
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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