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ELX-02 disulfate

产品编号 T19306 CAS 2244622-33-9

别名: NB-124 disulfate

ELX-02 disulfate (also referred to as NB-124 disulfate) is a synthetic eukaryotic ribosome selective glycoside (ERSG). This compound is currently in development as a therapy specifically designed to address genetic diseases resulting from nonsense mutations.

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ELX-02 disulfate, CAS 2244622-33-9

规格	价格/CNY		货期	数量
5 mg	￥ 8,150		待询
10 mg	￥ 12,400		待询

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其他形式的 ELX-02 disulfate:

ELX-02 sulfate
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ELX-02
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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	ELX-02 disulfate (also referred to as NB-124 disulfate) is a synthetic eukaryotic ribosome selective glycoside (ERSG). This compound is currently in development as a therapy specifically designed to address genetic diseases resulting from nonsense mutations.
体外活性	ELX-02 (100-400 μg/mL) is not toxic, and permits read-through of nonsense mutations in human cells.
体内活性	ELX-02 is rapidly eliminated from plasma in a biphasic manner with the terminal half-life (T1/2) of 0.5 h.??In a CtnsY226X nonsense mutant mouse, subcutaneous ELX-02 accumulates in kidney tissue without overt renal toxicity and that ELX-02 (10 mg/kg X2/week for 3 weeks) reduces renal cystine accumulation in vivo.ELX-02 (10 and 30 mg/kg;?repeat subcutaneous administration;?twice weekly, total of 8 doses) shows accumulation in tissues that is dose dependent without gender difference.?In plasma ELX-02 is rapidly absorbed with a Tmax of 0.25 h after both single (a single subcutaneous injection at 10 mg/kg at dose volume of 5 mL/kg) and repeated administration (twice weekly with 10 mg/kg/dose for 21 days;?total of 7 administrations).

别名	NB-124 disulfate
分子量	580.6
分子式	C19H40N4O14S
CAS No.	2244622-33-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 100 mg/mL (147.34 mM), Sonication is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
H2O	1 mM	1.7224 mL	8.6118 mL	17.2236 mL	43.0589 mL
	5 mM	0.3445 mL	1.7224 mL	3.4447 mL	8.6118 mL
	10 mM	0.1722 mL	0.8612 mL	1.7224 mL	4.3059 mL
	20 mM	0.0861 mL	0.4306 mL	0.8612 mL	2.1529 mL
	50 mM	0.0344 mL	0.1722 mL	0.3445 mL	0.8612 mL
	100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.4306 mL

计算器

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参考文献

1. Leubitz A, et al. Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Jan 16.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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