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Ro5类药天然产物库

Ro5类药天然产物库

现 货
产品编号 L6160 RO5 Drug-like Natural Product Library
  库化合物信息   Excel SDF

天然产物是先导化合物及候选药物的重要来源,其骨架结构复杂,官能团丰富,结构独特,多具有手性。这些自然形成的优势,为天然产物向药物的转化提供了更加多样的选择, 也是天然产物在药物开发与研究中发挥着重要作用的原因。

TargetMol 应用类药性评价指标“Lipinski 五规则”,基于天然产物结构的多样性和新颖性,优选出符合 RO5原则的 2743 个成药性良好的天然产物单体,涵盖萜类,生物碱类等多种结构类型,兼具生物活性和类药性,是新药发现、药物筛选和创新药物研究的有力工具。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
咨询化合物库
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产品描述

  • 2743种符合“Lipinski 五规则”的天然产物集合,成药潜力高;
  • 大部分化合物生物活性明确,具有抗肿瘤、抗炎、抗氧化、神经保护等多种功能;
  • 结构多样,包含黄酮、皂苷、萜类、生物碱等类别;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L6160)
点击图片重新获取验证码

客户使用化合物库发表的文献

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化合物库组成

Endogenous Metabolite (803)
Apoptosis (258)
Antibacterial (218)
Autophagy (170)
NF-κB (112)
Antifungal (102)
Antibiotic (85)
Reactive Oxygen Species (74)
Parasite (66)
COX (61)
Antioxidant (61)
AChR (53)
P450 (52)
Influenza Virus (44)
Anti-infection (43)
DNA/RNA Synthesis (42)
TNF (38)
AChE (38)
GABA Receptor (35)
p38 MAPK (35)
IL Receptor (32)
5-HT Receptor (32)
Calcium Channel (31)
Caspase (31)
Tyrosinase (31)
ERK (31)
Ferroptosis (29)
STAT (29)
HIV Protease (29)
Akt (29)
NO Synthase (28)
Estrogen/progestogen Receptor (27)
Topoisomerase (26)
Adrenergic Receptor (26)
Nrf2 (24)
Virus Protease (24)
AMPK (24)
TRP/TRPV Channel (22)
PI3K (21)
PPAR (21)
MMP (21)
ROS (21)
Lipoxygenase (20)
Dopamine Receptor (20)
Estrogen Receptor/ERR (20)
BCL (19)
NOS (19)
Potassium Channel (18)
Antifection (18)
PDE (18)
PKC (17)
Dehydrogenase (16)
HSV (16)
Microtubule Associated (16)
PARP (16)
JNK (16)
Nucleoside Antimetabolite/Analog (15)
EGFR (15)
Mitophagy (14)
iGluR (14)
Adenosine Receptor (13)
Glucosidase (13)
HDAC (13)
Histamine Receptor (13)
Prostaglandin Receptor (13)
Drug Metabolite (13)
Mitochondrial Metabolism (12)
Sodium Channel (12)
HIF/HIF Prolyl-Hydroxylase (12)
Amino Acids and Derivatives (12)
Antiviral (12)
VEGFR (12)
Androgen Receptor (11)
MAO (11)
P-gp (11)
Wnt/beta-catenin (11)
GluR (11)
ATPase (10)
Immunology/Inflammation related (10)
JAK (10)
NMDAR (10)
Glucocorticoid Receptor (10)
HBV (9)
CDK (9)
SARS-CoV (9)
Monoamine Oxidase (9)
Sirtuin (9)
Opioid Receptor (8)
TLR (7)
HCV Protease (7)
TGF-beta/Smad (7)
Phospholipase (7)
Progesterone Receptor (7)
NOD (7)
Indoleamine 2,3-Dioxygenase (IDO) (6)
HER (6)
HIF (6)
HMG-CoA Reductase (6)
Interleukin (6)
Beta Amyloid (6)
GPR (6)
Cannabinoid Receptor (6)
Chloride channel (6)
IκB/IKK (6)
MAPK (6)
Fatty Acid Synthase (6)
mTOR (6)
PKA (6)
Phosphatase (5)
Src (5)
Reductase (5)
Platelet aggregation (5)
AhR (5)
PAFR (5)
Reverse Transcriptase (5)
NADPH (5)
Xanthine Oxidase (5)
HSP (5)
transporter (5)
Carbonic Anhydrase (5)
FXR (5)
Gamma-secretase (5)
Transferase (5)
Aryl Hydrocarbon Receptor (5)
BACE (5)
LDL (4)
ribosome (4)
MEK (4)
CaMK (4)
FGFR (4)
ATP Citrate Lyase (4)
p53 (4)
c-Met/HGFR (4)
cAMP (4)
DNA Methyltransferase (4)
Serine/threonin kinase (4)
Arginase (4)
PGE Synthase (4)
UGT (4)
Syk (4)
CCR (3)
Trk receptor (3)
Serotonin Transporter (3)
IAP (3)
MRP (3)
DNA (3)
Beta-Secretase (3)
DHFR (3)
Tyrosine Kinases (3)
ROR (3)
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GSK-3 (3)
Telomerase (3)
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Imidazoline Receptor (3)
Thyroid hormone receptor(THR) (3)
Hedgehog/Smoothened (3)
Integrin (3)
GST (3)
Aromatase (3)
Glutathione Peroxidase (3)
GPCR19 (3)
Lipid (3)
Free radical scavengers (3)
FAK (3)
PDK (2)
PDGFR (2)
PKM (2)
ATM/ATR (2)
Casein Kinase (2)
Ras (2)
PAK (2)
PAI-1 (2)
Proteasome (2)
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Aurora Kinase (2)
Thrombin (2)
c-Myc (2)
Serine Protease (2)
IGF-1R (2)
RAAS (2)
Histone Acetyltransferase (2)
gp120/CD4 (2)
LTR (2)
Smo (2)
FAAH (2)
E1/E2/E3 Enzyme (2)
Aminopeptidase (2)
DPP-4 (2)
DYRK (2)
DNA gyrase (2)
Decarboxylase (2)
CXCR (2)
OAT (2)
DNA Alkylator/Crosslinker (2)
Cysteine Protease (2)
S6 Kinase (2)
NOD-like Receptor (NLR) (2)
RANKL/RANK (2)
S1P Receptor (1)
Transaminase (1)
Acyltransferase (1)
Somatostatin (1)
aconitase (1)
Stearoyl-CoA Desaturase (SCD) (1)
RAR/RXR  (1)
ROS Kinase (1)
SGLT (1)
Retinoid Receptor (1)
Antifolate (1)
Raf (1)
Factor Xa (1)
ABC (1)
IDO (1)
Hydroxylase (1)
Hydrogenase (1)
Hexokinase (1)
hCE (1)
GlyT (1)
FLT (1)
ALK (1)
IRE1 (1)
DNA Alkylation (1)
CYP19A1 (1)
CRISPR/Cas9 (1)
CFTR (1)
CD38 (1)
CAT (1)
Carboxypeptidase (1)
BCRP (1)
ATTECs (1)
IRAK (1)
Leukotriene Receptor (1)
Pyroptosis (1)
OCT (1)
Prolyl Endopeptidase (PREP) (1)
PLK (1)
Pim (1)
PD-1/PD-L1 (1)
PAD (1)
Adenylyl cyclase (1)
Adiponectin receptor (1)
P2Y Receptor (1)
P2X Receptor (1)
Norepinephrine (1)
LPL Receptor (1)
NMU2R (1)
advanced glycation end products (1)
Neurokinin receptor (1)
NADPH-oxidase (1)
MT Receptor (1)
Monocarboxylate transporter (1)
Monoamine Transporter (1)
Melatonin Receptor (1)
Mdm2 (1)
Liver X Receptor (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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