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Ro5类药天然产物库

Ro5类药天然产物库

产品编号 L6160 RO5 Drug-like Natural Product Library
  库化合物信息   Excel SDF

天然产物是先导化合物及候选药物的重要来源,其骨架结构复杂,官能团丰富,结构独特,多具有手性。这些自然形成的优势,为天然产物向药物的转化提供了更加多样的选择, 也是天然产物在药物开发与研究中发挥着重要作用的原因。

TargetMol 应用类药性评价指标“Lipinski 五规则”,基于天然产物结构的多样性和新颖性,优选出符合 RO5原则的 2703 个成药性良好的天然产物单体,涵盖萜类,生物碱类等多种结构类型,兼具生物活性和类药性,是新药发现、药物筛选和创新药物研究的有力工具。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
TargetMol Compound Library
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
咨询化合物库
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产品描述

  • 2703种符合“Lipinski 五规则”的天然产物集合,成药潜力高;
  • 大部分化合物生物活性明确,具有抗肿瘤、抗炎、抗氧化、神经保护等多种功能;
  • 结构多样,包含黄酮、皂苷、萜类、生物碱等类别;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L6160)
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TargetMol Library Books客户使用化合物库发表的文献

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化合物库组成

Endogenous Metabolite (788)
Apoptosis (255)
Antibacterial (213)
Autophagy (168)
NF-κB (112)
Antifungal (101)
Antibiotic (81)
Reactive Oxygen Species (73)
Parasite (66)
Antioxidant (61)
COX (60)
P450 (50)
AChR (46)
Influenza Virus (43)
Anti-infection (42)
DNA/RNA Synthesis (40)
AChE (38)
TNF (37)
p38 MAPK (35)
GABA Receptor (33)
IL Receptor (32)
Tyrosinase (31)
ERK (31)
Caspase (31)
Calcium Channel (30)
Akt (29)
HIV Protease (29)
5-HT Receptor (29)
STAT (28)
Ferroptosis (28)
NO Synthase (28)
Estrogen/progestogen Receptor (27)
Topoisomerase (26)
Adrenergic Receptor (26)
Virus Protease (24)
AMPK (24)
Nrf2 (22)
TRP/TRPV Channel (22)
PI3K (21)
PPAR (21)
MMP (21)
ROS (20)
Estrogen Receptor/ERR (20)
Lipoxygenase (20)
NOS (19)
Dopamine Receptor (19)
BCL (19)
PDE (18)
Antifection (18)
PKC (17)
Potassium Channel (17)
JNK (16)
Microtubule Associated (16)
Dehydrogenase (16)
PARP (16)
Nucleoside Antimetabolite/Analog (15)
HSV (15)
EGFR (15)
Mitophagy (14)
iGluR (13)
Histamine Receptor (13)
Drug Metabolite (13)
Adenosine Receptor (13)
HDAC (13)
Prostaglandin Receptor (13)
Mitochondrial Metabolism (12)
Glucosidase (12)
Antiviral (12)
Amino Acids and Derivatives (12)
Sodium Channel (12)
Wnt/beta-catenin (11)
VEGFR (11)
P-gp (11)
Androgen Receptor (11)
GluR (11)
MAO (11)
HIF/HIF Prolyl-Hydroxylase (11)
Glucocorticoid Receptor (10)
NMDAR (10)
Immunology/Inflammation related (10)
JAK (10)
ATPase (10)
HBV (9)
CDK (9)
SARS-CoV (9)
Monoamine Oxidase (9)
Sirtuin (8)
Opioid Receptor (8)
TGF-beta/Smad (7)
HCV Protease (7)
NOD (7)
Progesterone Receptor (7)
Phospholipase (7)
TLR (7)
Beta Amyloid (6)
Chloride channel (6)
MAPK (6)
Fatty Acid Synthase (6)
IκB/IKK (6)
GPR (6)
HIF (6)
Interleukin (6)
Indoleamine 2,3-Dioxygenase (IDO) (6)
HMG-CoA Reductase (6)
PKA (6)
mTOR (6)
AhR (5)
Src (5)
Xanthine Oxidase (5)
transporter (5)
FXR (5)
Transferase (5)
Cannabinoid Receptor (5)
Aryl Hydrocarbon Receptor (5)
Reverse Transcriptase (5)
Carbonic Anhydrase (5)
Gamma-secretase (5)
Phosphatase (5)
NADPH (5)
HER (5)
Reductase (5)
PAFR (5)
BACE (5)
Platelet aggregation (5)
MEK (4)
cAMP (4)
DNA Methyltransferase (4)
HSP (4)
FGFR (4)
UGT (4)
p53 (4)
PGE Synthase (4)
LDL (4)
ATP Citrate Lyase (4)
Serine/threonin kinase (4)
Syk (4)
c-Met/HGFR (4)
Arginase (4)
Telomerase (3)
Trk receptor (3)
Lipid (3)
Beta-Secretase (3)
Serotonin Transporter (3)
Free radical scavengers (3)
Tyrosine Kinases (3)
Proton pump (3)
Thyroid hormone receptor(THR) (3)
CaMK (3)
Hedgehog/Smoothened (3)
IAP (3)
GSK-3 (3)
Aromatase (3)
ribosome (3)
Integrin (3)
MRP (3)
ROR (3)
DHFR (3)
GST (3)
Glutathione Peroxidase (3)
FAK (3)
CCR (3)
Imidazoline Receptor (3)
Epigenetic Reader Domain (3)
GPCR19 (3)
PAI-1 (2)
Aminopeptidase (2)
ATM/ATR (2)
NOD-like Receptor (NLR) (2)
Thrombin (2)
Decarboxylase (2)
PDK (2)
Ras (2)
Casein Kinase (2)
PAK (2)
OAT (2)
PDGFR (2)
LTR (2)
DYRK (2)
RAAS (2)
gp120/CD4 (2)
c-Myc (2)
Serine Protease (2)
Cysteine Protease (2)
RANKL/RANK (2)
Amylase (2)
E1/E2/E3 Enzyme (2)
Phosphorylase (2)
DNA gyrase (2)
Smo (2)
DPP-4 (2)
PKM (2)
Proteasome (2)
Aurora Kinase (2)
DNA (2)
CXCR (2)
IGF-1R (2)
FAAH (2)
Melatonin Receptor (1)
Factor Xa (1)
Norepinephrine (1)
P2Y Receptor (1)
RAR/RXR  (1)
IRAK (1)
SGLT (1)
aconitase (1)
S6 Kinase (1)
BCRP (1)
NADPH-oxidase (1)
DNA Alkylator/Crosslinker (1)
NMU2R (1)
LPL Receptor (1)
CYP19A1 (1)
CD38 (1)
ROS Kinase (1)
Hydrogenase (1)
Monocarboxylate transporter (1)
CFTR (1)
Transaminase (1)
CAT (1)
PD-1/PD-L1 (1)
Adenylyl cyclase (1)
Mdm2 (1)
advanced glycation end products (1)
S1P Receptor (1)
FLT (1)
ATTECs (1)
OCT (1)
Raf (1)
ALK (1)
Pyroptosis (1)
Carboxypeptidase (1)
Monoamine Transporter (1)
Hexokinase (1)
Retinoid Receptor (1)
GlyT (1)
Stearoyl-CoA Desaturase (SCD) (1)
P2X Receptor (1)
hCE (1)
MT Receptor (1)
CRISPR/Cas9 (1)
Adiponectin receptor (1)
Neurokinin receptor (1)
IRE1 (1)
Prolyl Endopeptidase (PREP) (1)
IDO (1)
Somatostatin (1)
Hydroxylase (1)
PAD (1)
Leukotriene Receptor (1)
Acyltransferase (1)
Liver X Receptor (1)
Histone Acetyltransferase (1)
Antifolate (1)
Pim (1)
ABC (1)
PLK (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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