vasorelaxant

(±)-Naringenin (Naringenine) 是一种天然的类黄酮。它通过激活肌细胞中 BKCa 通道发挥对内皮剥脱血管的舒张作用。

Caroverine hydrochloride (Caroverine HCL) 是竞争性可逆的NMDA 和AMPA 谷氨酸受体拮抗剂。它也是抗氧化和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。

Vasorelaxant agent-1 (Compound 2j) 是一种可穿过血脑屏障的血管舒张剂，表现出显著的血管舒张活性，其EC50为0.02916 μM。Vasorelaxant agent-1 无致癌性，可用于高血压研究。

Methyl cinnamate 是花椒的有效成分，也是一种天然香料。它是一种防止食品褐变的酪氨酸酶抑制剂，具有抗菌活性。它通过由 CaMKK2-AMPK 信号途径介导的机制具有抗脂活性。

Ethyl cinnamate 是食品香料和化妆品添加剂，也是哺乳动物组织的优良清除剂。

Harmalol hydrochloride (Harmidol hydrochloride) 是一种可从Peganum harmala L.的种子中提取出来的β-咔啉生物碱。Harmalol hydrochloride 是Harmaline 的主要代谢产物，在转录和翻译后水平上显著抑制二恶英介导的 CYP1A1 诱导。Harmalol hydrochloride 在去氧肾上腺素或KCl 预先收缩的分离大鼠胸主动脉制剂中显示出血管松弛活性。 Harmalol hydrochloride 具有抗氧化活性.

Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity.

GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta.

Euxanthone (1,7-Dihydroxyxanthone) 是一种从 Polygala tenuifolia Willd 的根中提取的氧杂蒽酮衍生物，具有抗肿瘤、神经保护和血管松弛活性，可通过诱导自噬 (autophagy) 来减弱 Aβ1-42 诱导的氧化应激和细胞凋亡。Euxanthone 可诱导神经母细胞瘤神经 2A (BU-1) 细胞的分化。

CB096 is a novel inhibitor of RAN translation. specifically binds to a repeating 1 × 1 GG internal loop structure, 5'CGG 3'GGC, that is formed when r(G4C2)exp folds, also acting as a potent vasorelaxant agent, showing antihypertensive effect.

Isograndifoliol 是一种选择性丁酰胆碱酯酶 (BChE) 抑制剂，IC50值为 0.9 μM。Isograndifoliol 对乙酰胆碱酯酶 (AChE) 有一定的抑制作用，IC50值为 342.9 μM。Isograndifoliol 还具有血管松弛作用和抗肿瘤作用。Isograndifoliol 可用于研究神经退行性疾病引起的痴呆。

(R)-IDHP为IDHP异构体，属于丹参代谢物。该化合物能通过抑制血管平滑肌细胞电压依赖性钙通道与受体操作钙通道的Ca2+释放和Ca2+内流，发挥血管松弛作用，适用于心脑血管疾病研究。

ANP (1-30), frog 是蛙源心房肽的多肽片段。具有利钠、利尿和血管松弛作用。

Villocarine A为一种天然源自的吲哚生物碱类化合物，具有血管松弛作用。

(+)-Osbeckic acid，一种Tartary Buckwheat中提取的血管松弛剂，对Sprague-Dawley大鼠胸主动脉环展现出显著的血管舒张效应，其半数有效浓度(EC50)为887 μM。

Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱，有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。

Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂，在呼吸道疾病中有研究的价值，如过敏性哮喘等。

Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine xanthine oxidase (XOD) generated superoxide anion radical (O2-.).

Uvaol 存在于橄榄和初榨橄榄油中，具有抗炎、抗增殖和血管舒张活性。

ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the opening of K+ channels and the alteration on Ca2+ mobilization.

Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively.

Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Leachianone G shows potent antiviral

Saucerneol has significant cardiovascular effects such as vasorelaxant and negative inotropic actions.

10,11-EDT, a substrate for soluble epoxide hydrolase (sEH), is a metabolic derivative of adrenic acid and acts as an endothelium-derived hyperpolarizing factor with potent vasorelaxant effects [1].