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TargetMol产品目录中 "

substance p receptor

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  • 抑制剂&激动剂
    52
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    1
    TargetMol | Recombinant_Protein
  • 多肽产品
    33
    TargetMol | Peptide_Products
  • 染料试剂
    1
    TargetMol | Dye_Reagents
  • 天然产物
    2
    TargetMol | Natural_Products
  • 同位素
    1
    TargetMol | Isotope_Products
  • 检测抗体
    2
    TargetMol | Antibody_Products
  • Substance P Receptor Antagonist 1
    T10121225526-17-0
    Substance P Receptor Antagonist 1 has the potential function in gastrointestinal disorders, inflammatory diseases, respiratory, and central nervous system disorders.
    • ¥ 10600
    6-8周
    规格
    数量
  • Lanepitant 2HCl
    拉奈匹坦盐酸盐, LY-303870 dihydrochloride, LY303870 dihydrochloride, LY 303870 dihydrochloride, Lanepitant dihydrochloride
    T25616170508-05-1In house
    Lanepitant 2HCl 是一种非肽类神经激肽-1 受体拮抗剂,具有镇痛和抗炎活性。Lanepitant 2HCl 抑制 P 物质与神经激肽-1 受体的结合,抑制神经源性炎症和疼痛传递,可用于研究偏头痛等疼痛性神经病变类疾病。
    • ¥ 1300 TargetMol
    In stock
    规格
    数量
  • Aprepitant
    阿瑞匹坦, MK-869, MK-0869, L-754030, Aprepitant`
    T1743170729-80-3
    Aprepitant 是选择性和高亲和力的神经激肽1受体拮抗剂,Kd 值为86 pM。
    • ¥ 233
    In stock
    规格
    数量
  • Fosaprepitant dimeglumine
    福沙匹坦二甲葡胺, MK-0517, L785298, Fosaprepitant dimeglumine salt
    T1790265121-04-8
    Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。
    • ¥ 457
    In stock
    规格
    数量
  • Netupitant
    Ro 67-31898 000, 奈妥吡坦, CID 6451149
    T6905290297-26-6
    Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂,具有止吐作用,在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。
    • ¥ 189
    In stock
    规格
    数量
  • Galantide acetate
    Galantide acetate(138579-66-5 Free base)
    T15368L
    Galantide acetate 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂,是一种由甘丙肽和 P 物质片段组成的肽段,在大鼠下丘脑可识别两类甘丙肽结合位点 (KD 分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide acetate 似乎与单一的 SP 受体群结合 (KD~40 nM)。
    • ¥ 1270 TargetMol
    In stock
    规格
    数量
  • N-desmethyl Netupitant
    N-脱甲基奈妥吡坦, Netupitant metabolite N-desmethyl Netupitant
    T12212290296-72-9
    N-desmethyl Netupitant是 Netupitant 的代谢物,是一种潜在的 Substance-P 受体激动剂,可用于研究心血管疾病和神经系统疾病。
    • ¥ 11700
    8-10周
    规格
    数量
  • Vapreotide diacetate
    T13306L2936560-75-7
    Vapreotide diacetate is a synthetic analog of somatostatin. It has analgesic activity most likely mediated through the blockade of the neurokinin-1 receptor (NK1R), the substance P (SP)-preferring receptor.
    • ¥ 10600
    5日内发货
    规格
    数量
  • Spantide I
    Spantide
    T2041391224-37-2
    Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.
    • ¥ 8860
    待询
    规格
    数量
  • FR 113680
    FR113680,FR-113680
    T27360126088-92-4
    FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity.
    • 待询
    规格
    数量
  • YM49598
    YM-49598,YM 49598
    T29186738575-62-7
    YM49598 is a tachykinin receptor antagonist. YM49598 exhibited high binding affinities at NK(1) (pK(i) = 9.09 + - 0.02) and NK(2) (pK(i) = 9.94 + - 0.03) receptors, respectively. YM49598 was almost inactive but produced a potent inhibition (IC(50) = 11 +
    • ¥ 12800
    8-10周
    规格
    数量
  • CP-122721
    UNII-R7OYP6N58F,CP122721
    T31039145742-28-5
    CP-122721 is an NK1 receptor antagonist with a unique antidepressant, anti-anxiety, and antiemetic properties. It is also an effective selective substance P receptor antagonist.
    • ¥ 10600
    6-8周
    规格
    数量
  • Maropitant citrate
    马罗匹坦柠檬酸盐
    T35344359875-09-5
    Maropitant citrate 是一种合成的神经激肽-1 受体拮抗剂和 P 物质抑制剂,可用于控制猫狗的呕吐。
    • ¥ 369
    In stock
    规格
    数量
  • Biotin-Substance P
    T3711087468-58-4
    Biotin-Substance P 在中枢神经系统中作为神经递质和神经调节剂。神经激肽1受体 (neurokinin 1 receptor,NK1R)是 Biotin-Substance P 的内源性受体。
    • ¥ 10600
    待询
    规格
    数量
  • Rolapitant
    罗拉吡坦, SCH619734, 罗拉匹坦
    T3716552292-08-7
    Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂,Ki 值为0.66 nM。
    • ¥ 358
    In stock
    规格
    数量
  • Benzomalvin C
    T38276157047-98-8
    Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
    • ¥ 15980
    35日内发货
    规格
    数量
  • rolapitant hydrochloride hydrate
    T68371914462-92-3
    Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy.
    • ¥ 18300
    1-2周
    规格
    数量
  • Nolpitantium Free Base
    T70456155418-05-6
    Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no effect in bioassays for NK2 and NK3 receptors. The antagonism exerted by Nolpitantium toward NK1 receptors was apparently non-competitive, with pD2' values between 9.65 and 10.16 in the different assays. Nolpitantium also blocked in vitro [Sar9, Met(O2)11]substance P-induced release of acetylcholine from rat striatum. In vivo, Nolpitantium exerted highly potent antagonism toward [Sar9, Met(O2)11]substance P-induced hypotension in dogs, bronchoconstriction in guinea-pig) and plasma extrava......
    • ¥ 21600
    10-14周
    规格
    数量
  • Substance P(1-7)
    Substance P 1-7
    T739668060-49-1
    Substance P(1-7) (Substance P 1-7) 是神经肽P 物质的片段,可对孤束核产生抑制和缓和作用,具有抗炎、抗伤害和抗痛觉过敏的作用。
    • ¥ 678
    待询
    规格
    数量
  • Substance P (7-11)
    Substance P 7-11(TFA)
    T755451165-05-0
    Substance P (7-11) (Substance P 7-11(TFA)) 是神经肽物质P 的C-末端片段,可引起细胞内钙浓度的增加。
    • ¥ 282
    待询
    规格
    数量
    TargetMol | Inhibitor Sale
  • [Sar9,Met(O2)11]-Substance P TFA
    T75769
    [Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽NK1受体激动剂。
    • 待询
    规格
    数量
  • Spantide I TFA
    T75837
    Spantide I TFA 是substance P 的类似物,是选择性的神经激肽-1 受体 (NK1receptor) 的拮抗剂,其对NK1和NK2受体的Ki 值分别为 230 nM 和8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子IL-10,从而显著减少角膜穿孔。
    • 待询
    规格
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  • [pro9]-substance p
    T76079104486-69-3
    [Pro9]-Substance P 是一种有效的、可逆的、选择性的NK-1速激肽受体激动剂,其EC50为 0.93 nM。
    • 待询
    规格
    数量
  • [Glp5,(Me)Phe8,Sar9] Substance P (5-11)
    T7640477128-69-9
    [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) 是一种 Substance P 类似物,在大鼠大脑中对神经激肽 1 受体 (NK1R) 的作用与 Substance P 大致相等,但作用时间大大延长。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 能选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢。[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 还可增加大鼠运动活性,诱导成瘾剂寻求行为的恢复。
    • 待询
    规格
    数量