steroid 21-hydroxylase

Ketoconazole (R-41400) 是一种具有广谱抗真菌活性的咪唑类（imidazole）抗真菌药物，主要通过抑制真菌细胞膜中麦角固醇（ergosterol）的生物合成发挥作用。Ketoconazole 通过抑制真菌细胞色素 P450 依赖酶 lanosterol 14α-脱甲基酶（CYP51），阻断 lanosterol 向 ergosterol 的转化，导致细胞膜结构与通透性受损，从而抑制真菌生长并产生抗真菌作用。此外，Ketoconazole 也是一种非选择性细胞色素 P450（CYP）抑制剂，尤其可抑制人类 CYP3A4 等药物代谢酶。在内分泌方面，Ketoconazole 还可抑制多种类固醇合成相关酶（ CYP17A1、CYP11A1）。

Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4 1.Kamrath, C., Hartmann, M.F., Boettcher, C., et al.Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infantsJ. Steroid Biochem. Mol. Biol.15610-16(2016) 2.Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194105439(2019) 3.Disorders of steroidogenesis guide to steroid profiling and biochemical diagnosis1(2019) 4.Shackleton, C.H.L.Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesisLipids47(1)1-12(2012)

21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

16α-Hydroxyetiocholanolone is a metabolite of 16α-hydroxydehydroisoandrosterone (16α-DHEA) and androstenedione.1,2 1.Lai, E.Y., and Solomon, S.The in vivo metabolism of 16ɑ-hydroxydehydroisoandrosterone in manBiochemistry6(7)2040-2052(1967) 2.Christakoudi, S., Cowan, D.A., Christakudis, G., et al.21-hydroxylase deficiency in the neonate - trends in steroid anabolism and catabolism during the first weeks of lifeJ. Steroid Biochem. Mol. Biol.138334-347(2013)

21-Deoxycortisol-D8是21-Deoxycortisol (T36915)的氘代化合物。21-Deoxycortisol的CAS号为641-77-0。

21-Deoxycortisol (Standard) 是一种可用于分析的标准物质，通常用作 21-Deoxycortisol 的研究和分析中参考的标准样品。21-Deoxycortisol 是 17-羟孕酮的一种皮质类固醇代谢产物，由肾上腺通过 11-羟化作用由 11β-羟化酶生成。在患有先天性肾上腺增生症且 CYP2A21 基因（编码类固醇 21-羟化酶的基因）发生杂合突变的患者中，其血清 21-脱氧皮质醇水平会升高，并且已被用作检测 21-羟化酶缺陷的生物标志物。

21-Deoxycortisol-D8 (Standard) 是 21-Deoxycortisol-D8 的标准品，适用于定量分析、质量控制及生化实验等相关研究。21-Deoxycortisol-d8 是 21-Deoxycortisol 的氘代化合物。21-Deoxycortisol 的 CAS 号为 641-77-0。