sp 10

Peptide originally derived from SARS-CoV Spike (S) protein; corresponds to amino acid residues 668 to 679. Highly potent inhibitor of SARS-CoV S protein and ACE2 interaction (IC50 = 1.88 nM in biochemical assay). Inhibits interaction of SARS-CoV S protein and Vero E6 cells in vitro. Please note, this peptide displays 80% sequence identity to homologous site on SARS-CoV-2 S-protein (residues 689-697).

表面活性蛋白A（SP-A）（196-215）是一种合成肽，与人类SP-A的C末端碳水化合物识别域的196至215氨基酸序列相对应。当浓度为1和10 µM时，它能抑制JAWSII鼠树突细胞中由LPS诱导的TNF-α释放。SP-A（196-215）（75 µM）促使JAWSII细胞吞噬P. aeruginosa。通过气管内给药，SP-A（196-215）（50 µg/动物）降低了小鼠P. aeruginosa感染模型的疾病严重程度和肺部形成菌落数。

PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP), gastrin releasing peptide (GRP),