This is amino acids 427 to 441 fragment belongs to the FliC, serotype a of the S. FliC epitope recognized by a CD4+ T cell from naturally infected C57BL/6 mice is located in a region common to a number of distinct Salmonella serovars such as the S. paraty
Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis 是来自肠道沙门氏菌血清型致肠炎的脂多糖内毒素和 TLR-4 激活剂,属于 S 型 LPS,能够激活免疫系统的致病相关分子模式 (PAMP),同时诱导细胞分泌迁移体。它具有典型的三部分结构:O 抗原、核心寡糖和脂质 A。此外,Lipopolysaccharides, from S. enterica serotype enteritidis 可以诱发全身炎症反应,导致血浆中 TNF-α、IFN-γ、IL-6、IL-10 及硝酸盐水平升高。
Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype typhimurium 是来自血清型沙门氏菌的脂多糖内毒素及TLR4激活剂,属于S型LPS。该化合物具有典型的三部分结构:O抗原、核心寡糖和脂质A。它能够调控细菌在树突状细胞(DC)内的命运,影响DC对细菌的摄取、降解和免疫功能的激活。
Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor. [2] Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM [3] . Ganglioside GT1b mixture contains ganglioside GT1b molecular species with C18:1 and C20:1 sphingoid backbones.
UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in fungi and lipopolysaccharide production in bacteria.2,3 1.Roseman, S.Reflections on glycobiologyJ. Biol. Chem.276(45)41527-41542(2001) 2.Kudo, F., and Eguchi, T.Biosynthetic genes for aminoglycoside antibioticsJ. Antibiot. (Tokyo)62(9)471-481(2009) 3.Mulrooney, E.F., Poon, K.K., McNally, D.J., et al.Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11J. Biol. Chem.280(20)19535-19542(2005)