rat d4

ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.

Iloperidone (HP 873) 是一种D2/5-HT2受体拮抗剂，是非典型抗精神病药，可治疗精神分裂症。

Sonepiprazole 是D4多巴胺受体选择性拮抗剂，与rD4多巴胺受体，hD4.2多巴胺受体，rD2多巴胺受体和组胺H1受体结合的Ki 分别为 3.6、10.1、5147 和 7430 nM。

Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂，Ki 为 0.812 和 0.142 nM，是一种非典型的抗精神病试剂。

NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)

Fananserin 是一种有效的、特异性的、口服活性的 5-HT2 拮抗剂（大鼠 5-HT2A 的 Ki = 0.37 nM）。 Fananserin 是人 D4 受体的拮抗剂 (Ki = 2.93 nM)。

L-750667 是一种选择性的多巴胺 D4 受体拮抗剂配体。I 标记的 L-750667 能特异性地结合到大鼠视网膜中的多巴胺 D4 受体，Kd值为 0.06 nM。L-750667 能参与调节光敏感的 cAMP 池。

KF-17625 是一种口服活性的支气管扩张剂。它能够抑制由 Carbachol、Histamine 或 Leukotriene D4 引起的支气管收缩。KF-17625 抑制犬气管中的磷酸二酯酶 (PDE) IV，其 IC50 值为 12 μM；并在 10 μM 浓度下，以 44% 的抑制率抑制 Concanavalin-A 诱导的大鼠肥大细胞释放组胺 (histamine)。KF-17625 可用于免疫学和炎症研究。

ABT 724 trihydrochloride 是一种有效的选择性 D4 受体激动剂（EC50 = 12.4 nM，14.3 nM 和 23.2 nM，分别对人、大鼠和雪貂）。 ABT-724 trihydrochloride 可用于勃起功能障碍研究。

(+)-AJ-76是一种多巴胺自身受体 (dopamine autoreceptor) 的拮抗剂，对突触后多巴胺受体具有较弱的拮抗作用。(+)-AJ 76 HCl能够提高大鼠大脑多巴胺的合成和周转，还能够拮抗低剂量阿扑吗啡的镇静作用。

Iloperidone hydrochloride is a D(2)/5-HT(2) receptor antagonist. It is also an atypical antipsychotic for the treatment of schizophrenia symptoms.

PD 89211 is a selective dopamine D4 receptor antagonist with high selectivity for the DA D4.2 receptor (> 800-fold) as compared to other hDA receptor subtypes, rat brain serotonin, and adrenergic receptors. In vitro, PD 89211 reverses quinpirole-induced [

Nifuroxazide-D4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide (T1563) is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni,Salmonella,Y. enterocolitica,Shigella,and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide (T1563)inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells,which have constitutive STAT3 phosphorylation,with EC50 values of approximately 4.5 µM for both. It also decreases viability,migration,and invasion of,and induces apoptosis in,MCF-7,4T1,and MDA-MB-231 breast cancer cells. Nifuroxazide (T1563)reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea,weight loss,and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.

Gliclazide-D4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide (T1527) is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP)channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (T1527) (5 μM)increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4)translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin resistance induced by hydrogen peroxide. Gliclazide (T1527) (5 and 10 μg/ml)reduces LDL oxidation by human aortic smooth muscle cells (HASMCs),decreasing TBARS content and 8-isoprostane levels. It also decreases oxidized LDL-induced HASMC proliferation and monocyte adhesion when used at concentrations ranging from 1 to 10 μg/ml. Gliclazide (T1527) (5 mg/kg)reduces serum glucose levels and increases glucose uptake by isolated rat hindquarters in a model of diabetes induced by streptozotocin (STZ).

6-hydroxy Buspirone是抗焦虑化合物buspirone的活性代谢产物，通过细胞色素P450（CYP）亚型CYP3A4从buspirone转化而来。该化合物在大鼠海马和背侧缝核的5-羟色胺（5-HT）受体亚型5-HT1A上具有亲和力（EC50s分别为4和1 µM），并作为多巴胺D2、D3、D4受体拮抗剂（IC50s分别为3.1、4.9、和0.85 µM）。同时，它还以浓度依赖性方式抑制表达人类转运体的S2近端小管细胞中的有机阳离子转运体1（OCT1）、OCT2和OCT3。

N-Palmitoyl taurine-d4 是氘标记的 N-Palmitoyl taurine。这种化合物是一种在脂质组学分析过程中从大鼠脑中分离得到的关键氨基酰基内源性大麻素，目前其具体功能仍在研究中。

N-Stearoyl Taurine-d4 是氘标记的 N-Stearoyl taurine，这是一种关键的氨基酰基内源性大麻素，可在脂质组学分析中从大鼠脑中提取。