pyridone

TCS PIM-1 1 (SC 204330) 是一种特异性有效的 ATP 竞争性 Pim-1 激酶抑制剂，IC50为 50 nM，对 MEK1 MEK2 和 Pim-2 表现出良好的特异性，IC50值大于 20000 nM。

α-Pyridone (2-Hydroxypyridine) 是内源性代谢产物的一种。

Pyridone 6 (JAK Inhibitor) 是一种泛JAK 抑制剂，有效抑制 JAK 激酶家族，对JAK2、TYK2、JAK3和JAK1的IC50分别为 1、1、5 和 15 nM。

Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase(IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively), and induces p130Cas cleavage and apoptosis and has anticancer effects.

Aspyridone A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6092，CAS号为 935863-26-6。

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

NITD-916 是一种具有口服活性和高度亲脂性的分枝杆菌烯酰还原酶 InhA 抑制剂，IC50 为 570 nM。NITD-916是一种有有效的 4-羟基-2-吡啶酮衍生物， 与 InhA 和 NADH 形成三元复合物，阻止进入脂肪酰基底物结合袋。NITD-916 具有抗结核活性。

ABT-255 is a novel 2-pyridone antimicrobial agent for the treatment of tuberculosis. Both drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis showed efficacy in vitro and in vivo.

RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.

Iromycin A is a bacterial pyridone metabolite that inhibits nitric oxide synthase (NOS) activity, with selectivity for NOS III (endothelial NOS) over NOS I (neuronal NOS). Iromycin metabolites and derivatives block NADH oxidation in beef heart submitochondrial particles (IC50 = 0.461 μM for iromycin A).

Cap-dependent endonuclease-IN-16 是一种吡啶酮多环衍生物，也是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-16 表现出潜力进行流感的研究 。

PD 163449 is a bioactive molecule of 4-pyridone group that inhibits bacterial type IIA topoisomerase (DNA gyrase and topoisomerase IV).

Paecilomide，吡啶酮生物碱，是一种乙酰胆碱酯酶 (acetylcholinesterase) 抑制剂。

HCT-116-IN-1, 一种与γ-内酰胺融合的吡啶酮衍生物，展现了针对HCT116细胞的强抗癌活性，其细胞毒性测定显示IC50值为5.59 μM。