prion

TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) 是一种抗朊病毒剂，可抑制蛋白酶抗性朊病毒蛋白的积累。它诱导神经鞘瘤细胞调亡，在ScN2a 和F3细胞株中均显示IC50值为3 nM。

Prion peptide fragment that exhibits neurotoxicity

Icerguastat (IFB-088) 是一种缺乏 α2-肾上腺素能活性的 Guanabenz 衍生物，是一种磷酸酶调节亚单位 PPP1R15A (R15A)的选择性抑制剂。它能够抑制 eIF2α 去磷酸化，从而延长保护反应。它具有抗朊病毒作用。

Tetracycline (Tetracyclin) 是一种广谱抗生素，对多种革兰氏阳性和革兰氏阴性细菌有抑制活性，对支原体、支原体和立克次体等也有活性。Tetracycline 常用于抗感染研究。

Prionoid E 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124011。

Prionoid D 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124012。

Prionoid C 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124013。

Prionoid B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124014。

Salprionin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125601。

Prionitin is a natural product from Salvia prionitis Hance.

Prionidipene A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5590，CAS号为 2199455-72-4。

Prionanthoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6502，CAS号为 161842-81-5。

NT219 是一种胰岛素受体底物 1 2 (IRS1 2) 和STAT3的双重抑制剂，可增强错误折叠的朊病毒蛋白的聚集NT219 影响，可提高某些分子伴侣的水平，抑制 STAT3 磷酸化。NT219 具有研究癌症和神经退行性疾病。

IND24 具有抗朊病毒活性，可用于研究神经退行性疾病。

TGFβ-IN-5 (WAY-641966) 是一种有效的 TGFβ 抑制剂，具有抗朊病毒活性，可用于研究与 TGF-β 信号转导相关的纤维增殖性疾病。

PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation(IC50 of 1.6 μM), with anti-prion activity.

GFP16 是具有潜在抗朊病毒活性的化合物，可用于研究朊病毒。

Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e

DB772 是一种广谱抗病毒活性，抑制牛病毒性腹泻病毒(BVDV)、朊病毒活性、边界病病毒(BDV)、HoBi病毒、叉角病毒和Bungowannah病毒。

IND81 is an antiprion agent that works by extending the lives of prion-infected animals.

Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.

Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid isolated from T. titanicus that at a dose of 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.

Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington's disease.

6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 μM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 μM and in adults following dietary administration of 1-3 mM doses. 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.