ph 20

Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.

Zika virus NS5 is involved in methytransferase and RNA guanylytransferase activities and capping and synthesis of RNA. And, NS5 is also an RNA-dependent RNA polymerase.

Zika virus (ZIKV) (strain Zika SPH2016) ZIKV-E (Stem anchor domain of flavivirus envelope glycoprotein E) protein (Fc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is ALU33341.1.

Zika virus (strain Zika SPH2015) E Envelope protein (His) is expressed in yeast with His tag. The predicted molecular weight is 12.9 kDa and the accession number is ALU33341.1.

Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E Envelope protein (Fc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 38.2 kDa and the accession number is ALU33341.1.

Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E Envelope protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is ALU33341.1.

Zika virus NS1 antigen is one of seven non-structural proteins. NS1 is involved in RNA replication. The possible effects of NS1 on hosts include: localizes to host cell surface and secreted extracellularly, modulates signalling of the innate immune system, has possible damages to platelets and endothelial cells through anti-NS1 antibodies.

Zika virus (strain Zika SPH2015) E Envelope protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 57.2 kDa and the accession number is ALU33341.1.

Zika virus (ZIKV) (strain Zika SPH2015) E Envelope protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 45.5 kDa and the accession number is ALU33341.1.

Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E Envelope protein (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is ALU33341.1.

Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. ZIKV has a more selective and larger impact on the expression of genes involved in DNA replication and repair. P53 inhibitors can block the apoptosis induced by ZIKV-M in hNPCs.

Zika virus (ZIKV) (strain Zika SPH2015) E Envelope protein (aa 291-696, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 45.6 kDa and the accession number is ALU33341.1.

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.