peroxisomal

Lignoceric Acid (tetracosanoic acid) 是一种 24 碳饱和 (24:0) 脂肪酸，在发育中的大脑中合成，也是一种木质素生产的副产品。它能够用于研究 Zellweger 脑-肝-肾综合征和肾上腺脑白质营养不良。

L-Pipecolic acid (L-Homoproline) 是赖氨酸的分解产物，它能在患有常染色体遗传性疾病的婴儿体液中积累，比如新生儿肾上腺机能障碍， Zellweger 综合征等。

Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。

Tridecanedioic acid (Brassilic acid) 是内源性代谢产物的一种。

1-O-Hexadecyl-sn-glycerol 是一种具有生物活性的烷基甘油醚，能够通过减少角质形成细胞死亡、降低活性氧（ROS）的生成以及抑制前列腺素 E2 的合成，对紫外线 B（UVB）诱导的细胞损伤发挥保护作用。在正常人表皮角质形成细胞（NHEKs）中，1-O-Hexadecyl-sn-glycerol表现出显著的细胞保护效应。此外，在 50 μM 浓度下，1-O-Hexadecyl-sn-glycerol 在离体大鼠心脏缺血再灌注模型中显著提高冠状动脉流量和左心室发展压，同时减少丙二醛（MDA）的生成，展现出细胞保护性与心脏保护性双重药理特征。

12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger's Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound.

Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid .1 Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder characterized by mutations in PEX genes which result in defects in peroxisome formation.2,3 |1. Keane, M.H., Overmars, H., Wikander, T.M., et al. Bile acid treatment alters hepatic disease and bile acid transport in peroxisome-deficient PEX2 Zellweger mice. Hepatology 45(4), 982-997 (2007).|2. Ferdinandusse, S., Overmars, H., Denis, S., et al. Plasma analysis of di- and trihydroxycholestanoic acid diastereoisomers in peroxisomal α-methylacyl-CoA racemase deficiency. J. Lipid Res. 42(1), 137-141 (2001).|3. Klouwer, F.C.C., Berendse, K., Ferdinandusse, S., et al. Zellweger spectrum disorders: Clinical overview and management approach. Orphanet J. Rare Dis. 10, 151 (2015).

Urate oxidase (Uox) 尿酸氧化酶，即尿酸酶，常用于生化研究。Urate oxidase 是一种过氧化物酶，在大多数哺乳动物中催化尿酸氧化为尿囊素。

Acyl-CoA oxidase (ACO) 催化脂肪酸在过氧化物酶体中的 β-氧化的初始步骤和限速步骤，并且是过氧化氢 (H2O2) 的主要生成者。