penicillin-binding protein

Tebipenem Pivoxil (Orapenem) 是一种碳青霉烯类新型口服抗生素。

Meropenem (SM 7338) sodium 是一种碳青霉烯类抗生素，具有广泛的抗微生物活性。该化合物对于敏感及耐药性强的淋病奈瑟氏球菌 (MIC 0.02-0.06 mg mL)、流感嗜血杆菌 (MIC 0.03-0.12 mg mL) 及杜克氏杆菌 (MIC 0.015-0.12 mg mL) 均显示出显著的抑制效果。

Piperacillin hydrate 是一种半合成广谱 β-内酰胺类抗生素，通过青霉素结合蛋白对革兰阴性菌和某些革兰阳性菌有强杀菌活性。它通常与 β-内酰胺酶抑制剂Tazobactam联合使用。

Cephalexin (Cephacillin) 是一种强口服活性的头孢菌素抗生素。它通过破坏细菌细胞壁的生长来杀死革兰氏阳性和一些革兰氏阴性细菌。它可研究肺炎、链球菌性咽喉炎、细菌性心内膜炎等。

Amoxicillin trihydrate (Moxaline trihydrate) 是一种中谱β内酰胺抗菌素。

Cefaclor monohydrate (Cefaclorum) 是一种抗生素，可特异性地结合青霉素结合蛋白。

Cefotaxime 是头孢类抗生素和耐内酰胺酶的头孢菌素，具有抗革兰氏阳性菌和革兰氏阴性菌的作用。

Cefbuperazone Sodium is a penicillin-binding protein inhibitor. It is used as antibacterials.

Mecillinam (Hexacillin) 是一种有抗革兰氏阴性菌活性的 β 内酰胺类广谱抗生素。

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudomonas, binding to each protein to induce derepression of various genes.2

Cefaclor (Panoral) 是一种可特异性结合青霉素结合蛋白的抗生素。

Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline.

Antibacterial agent 116 是一种含二苯甲酮的水杨酰苯胺类化合物。Antibacterial agent 116 能抑制肽聚糖的形成而具有较强的抗菌活性。Antibacterial agent 116 可作为光亲和探针标记 Acinetobacter baumannii 的青霉素结合蛋白 (PBP1b)，干扰肽聚糖链的生长，阻断其增殖。

Tebipenem pivoxil (L084) hydrochloride 是具口服活性、对多种致病菌有效的抗生素。通过结合青霉素结合蛋白 (PBP) 抑制细胞壁合成。

Carumonam Sodium is a monobactam, penicillin-binding protein inhibitor. It is used as antibacterials.

SIGSLAK 拥有与大肠杆菌青霉素结合蛋白 1b (PBP1b) 活性位点相对应的结构特征。