pe

Prolyl Endopeptidase在多个器官如大脑中展现出显著活性,主要通过降解含脯氨酸的多种肽类,如P物质、神经紧张素、黄体生成素释放激素、促甲状腺素释放激素、缓激肽及血管紧张素II等来发挥作用.该酶在应激障碍、抑郁症和精神分裂症等神经精神疾病的研究中具有重要应用价值.

Phosphatidylethanolamine (PE) 是一种存在于哺乳动物体内的磷脂，通过磷酯酰丝氨酸的脱羧作用形成。

18:0 LYSO-PE是一种诱导[Ca2+]i增加的化合物，18:0 LYSO-PE可用作电喷雾质谱（ESI-MS） MS进行脂质分析的磷脂（PL）标准。

1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p 22:6-PE) 为一种通过质谱成像技术在大鼠脑组织中确认的独特结构脂质，此方法可准确识别其不同脂肪酸链的异构体及其分布。

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine（18:0-22:6 PE）是一种用于构建脂质体的关键脂质成分。脂质体以其同心磷脂双层膜结构主要用于抗癌和抗感染的药物递送系统中。该化合物能够在其水性内部空间包裹高极性水溶性药物，同时将亲脂药物整合入脂质双层。它尤其适用于递送反义寡核苷酸，有效解决细胞内吸收不足和药物体内迅速丢失的问题。

18:1 PE (DOPE) pSar25 是聚乙二醇的衍生物，适用于脂质体和脂质纳米颗粒的递送系统。

DNS-pE is the first small molecule that can selectively label endogenous 3-phosphoglycerate dehydrogenase (PHGDH) from various mammalian cells.

1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid. [1] It inhibits the growth of L. donovani promastigotes (GIC50 = 8 uM). [2]1-Palmitoyl-2-hydroxy-sn-glycero-3-PE serum levels are decreased in a mouse model of alcohol-induced liver injury and in a hepatocellular carcinoma mouse xenograft model. [3] Human serum levels are also decreased immediately and 14 hours following an exercise regimen of 2.5 hours of running for three days. [1]1-Palmitoyl-2-hydroxy-sn-glycero-3-PE has been used as an internal standard for the quantification of saturated lysophosphoethanolamines. [4]

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1] It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3]

1-Myristoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid. It induces transient increases in intracellular calcium in PC12 cells. Serum levels of 1-myristoyl-2-hydroxy-sn-glycero-3-PE are elevated in patients with malignant breast cancer compared to healthy controls.

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes.

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in cellular membranes. It has been used in studies involving the biosynthesis of anandamide via the phospholipase A2 (PLA2) and lysoPLD pathways. PLPE can also be used as a specific substrate to assess the activity of sPLA2-IIA in the presence of other phospholipids.

PE859 是 tau 和 Aβ 聚集的有效抑制剂，IC50值分别为 0.66 和 1.2 μM。

PE(10:0 10:0) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T66959。

14: 0 PEG2000 PE (DMPE-PEG2000) 是一种聚乙二醇 （PEG）-磷脂偶联物，可在制备囊泡制剂时阻止囊泡聚集，可用于制备纳米结构脂质载体。

18:1 PEG-PE 是一种聚乙二醇 磷脂酰乙醇胺偶联物，可用于活性分子输送。

PE 22-28为TREK-1抑制剂，具有0.12 nM的IC50值。该化合物也是包含7个氨基酸的肽，作为通过化学修饰与氨基酸替换来制备类似物的关键序列。PE 22-28可用于抑郁症研究。

1,3-Dipalmitoyl glycero-2-phosphatidylethanolamine is a phospholipid incorporating saturated long-chain (16:0) stearic acid at the sn-1 and sn-3 positions, with phosphatidylethanolamine (PE) at the sn-2 position. Phosphatidylethanolamines, critical components of biological membranes, play essential structural and functional roles. Various PE types are instrumental in forming micelles, liposomes, and other synthetic membranes.

1-Palmitoyl-3-oleoyl-sn-glycero-2-PE 是一种活性分子，可用于生命科学相关研究，其 CAS 号为 884324-34-9。

1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-PE, a phospholipid comprising palmitic acid (at the sn-1 position) and docosahexaenoic acid (at the sn-2 position), is present in the nucleus of mouse liver but absent from mitochondria. Notably, its levels in pre-term infant plasma are lower compared to those in maternal or fetal plasma.

1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PE, a phospholipid comprising palmitic acid and arachidonic acid at the sn-1 and sn-2 positions respectively, is identified in egg yolk and isolated rat retina.

1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE, a plasmalogen, incorporates 1(Z)-hexadecenoic acid and palmitic acid at the sn-1 and sn-2 positions, respectively.

1-1(Z)-Hexadecenyl-2-palmitoyl-d9-sn-glycero-3-PE serves as an internal standard for quantitating 1-1(Z)-hexadecenyl-2-palmitoyl-sn-glycero-3-PE, which is a plasmalogen incorporating 1(Z)-hexadecanoic acid and palmitic acid at the sn-1 and sn-2 positions respectively, in analyses performed using GC- or LC-MS.