p-8

Laminin B1 octapeptide P-8 is a synthetic laminin B1 chain octapeptide with laminin receptor binding ability.

GP-82996 (CINK4) (CINK4) 是 CDK4 6的药理学抑制剂。GP-82996 对 CDK4 cyclin D1、CDK6 cyclin D1 和 Cdk5 p35 的 IC50s 分别为 1.5、5.6 和 25 μM。GP-82996 诱导肿瘤细胞 U2OS 的凋亡，可用于癌症研究。

TTP-8307 是一种抗病毒化合物，抑制鼻病毒和肠道病毒复制，通过干扰病毒 RNA 的合成抑制 coxsackievirus B3 病毒 和 poliovirus 病毒。TTP-8307 可用于研究病毒感染。

CP-866087 是一种新型、有效和选择性的μ阿片受体拮抗剂，用于研究女性性功能障碍。

CP-810123 是一种新的α 7 nAChR 激动剂，可用于治疗与精神分裂症和阿尔茨海默病等精神或神经疾病相关的认知障碍。

NSP-805 是一种强心剂，是一种选择性的 phosphodiesterase 3 抑制剂，具有舒张血管的作用。

13-Oxopodocarp-8(14)-en-18-oic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2619，CAS号为 63976-69-2。

ASP8497 is a potent, long-acting DPP-IV inhibitor that improves glucose tolerance by elevating GLP-1 levels in a glucose-dependent insulin-stimulating manner. The compound is used as a therapeutic agent for impaired glucose tolerance and type 2 diabetes.

CP-85958 is a cysteinyl leukotriene antagonist.

CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96 7.19 6.81 for human 5-HT2C 5-HT2B 5-HT2A receptors).

Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3]

Sp-8-Br-cAMPS 为 cAMP 的类似物，具有激动剂功能，能有效激活蛋白激酶 A (PKA)，具体活性表现为 EC50 为 360 nM。此外，Sp-8-Br-cAMPS 还能抑制鳞翅目幼虫的 T 细胞增殖与血细胞的非自身反应。

CP-8668 is an orally active nonsteroidal progesterone receptor modulator with tetrahydrobenzoindolone skeleton.

CP-8754 is a bio-active chemical. Detailed information has not been published.

Urotensin-II (UT) receptor ligand; behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays. Competitively antagonizes U-II induced contractions in the rat

Rp-8-CPT-cAMPS is a powerful and competitive antagonist of cAMP-induced activation of cAMP-dependent protein kinase (PKA) I and II. Acting as a potent cAMP analog, Rp-8-CPT-cAMPS exhibits a preference for site A of RI over site A of RII. Additionally, it favors site B of RII over site B of RI. This compound effectively inhibits cAMP-dependent PKA activation and demonstrates selectivity in binding to specific sites within the protein kinase.

Sp-8-pCPT-cGMPS 是一种对CNG通道具有高激活作用的化合物(cyclic guanosine monophosphate-gated channel)，并且作为 PKG (I α、I β 和 II 型) 以及 PKA II 型的疏水性活化剂显示出色的细胞膜穿透能力和对磷酸二酯酶的高稳定性。此外，Sp-8-pCPT-cGMPS 还常用于探究 cGMP 在神经可塑性及突触功能中的调控机制。

Sp-8-Br-2'-O-Me-cAMPS 为一种cAMP 类似物,同时作为EPAC激活剂,主要应用于代谢相关的研究领域.

Rp-8-pCPT-cGMPS 是一种具有高脂溶性的 cGMP 依赖性蛋白激酶 (PKG) 竞争性抑制剂,其抑制常数 (Ki) 为 0.5 μM.此化合物能轻易穿透细胞膜,于细胞内聚集达到有效浓度,从而抑制 cGMP 依赖性蛋白激酶的活性.Rp-8-pCPT-cGMPS 常用于探究血小板中 cGMP 依赖性蛋白激酶的活性与功能.

KP-81是一种结构复杂的芳香族化合物，可用于有机合成和药物设计。

Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.

SNAP-8719 is a selective antagonist of α1D-AR. SNAP-8719 showed better selectivity for α1D-AR and lower binding affinity for the 5-HT1A receptor.

FLDP-8, 一种姜黄素类似物，有效抗癌，能诱导LN-18细胞死亡，IC50值达4 μM。

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.